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Ch_8_Membrane_Transport - Ions(e.g Na K Cl Yes No Yes No No...

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Membrane Transport Biol-003 Spring 2010 1 A. Review of transport processes 1. Simple diffusion a. Size—lipid bilayer more permeable to smaller molecules b. Polarity—lipid bilayer more permeable to nonpolar molecules c. Ionic—lipid bilayer highly impermeable to ions 2. Osmosis a. Hypertonic solution b. Isotonic solution c. Hypotonic solution 3. Facilitated diffusion (carrier proteins) a. Example—facilitated diffusion of glucose 4. Facilitated diffusion (channel proteins) 5. Active transport a. Indirect vs. direct active transport b. Example—Na+/K+ pump c. Example—Na+/glucose symporter Properties Simple Diffusion Facilitated Diffusion Active Transport Solutes transported Small nonpolar (e.g., oxygen) Large nonpolar (e.g., fatty acids) Small polar (e.g., water, glycerol) Large nonpolar (e.g., glucose)
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Unformatted text preview: Ions (e.g., Na+, K+, Cl-) Yes No Yes No No No Yes Yes Yes Yes No No No Yes Yes Thermodynamic properties Direction relative to electrochemical gradient Effect on entropy Metabolic energy required Intrinsic directionality Down Increased No No Down Increased No No Up Decreased Yes Yes Kinetic properties Membrane protein mediated Saturation kinetics Competitive inhibition No No No Yes Yes Yes Yes Yes Yes B. Transport Kinetics 1. Uncharged solutes--∆G depends on concentration gradient a. S outside → S inside b. ∆G = ∆G o + RT ln [S inside ]/[S outside ] c. K eq = [S inside ]/[S outside ] = 1 d. ∆G o = 0 e. ∆G inward = + RT ln [S inside ]/[S outside ] 2. Charged solutes−∆G depends on electrical potential a. Need to take into account concentration gradient and membrane potential...
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