grignardreaction-091103134817-phpapp01

grignardreaction-091103134817-phpapp01 - Grignard Reaction...

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Grignard Reaction: Grignard Reaction: Preparation of Preparation of Triphenylmethanol Triphenylmethanol
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Background Background ¾ Grignard reagents are highly reactive organometallic reagents generated by treating alkyl or aryl halides with magnesium metal in the presence of an anhydrous ether. ¾ The reaction proceeds like a strong base reaction. ¾ This reagent was discovered by Victor Grignard around 1900. R'-X + Mg [ R'-X ] - +M g + R' - MgX δ - δ
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Background Background ¾ A Grignard reagent is capable of reacting with many different substrates such as carbonyl compounds, alkyl halides and other organometallic reagents. ¾ The addition of Grignard reagents to carbonyl compounds such as aldehydes, ketones, and esters yields the corresponding secondary and tertiary alcohols . ¾ The Grignard reaction results in the formation of a carbon-carbon bond . ¾ Grignard reagents are extremely strong bases that can react violently with hydroxylic compounds such as water or alcohols:
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Experimental Techniques C O OCH 3 + MgBr COMgBr 3 ¾ In the laboratory, initiation of the Grignard reaction is sometimes very slow. Because of the presence of air, a coating of magnesium oxide forms on the magnesium metal turnings. ¾ To initiate the reaction, adding a small crystal of iodine or a drop of dibromoethane can help to clean the surface of the magnesium. ¾ Today's experiment is preparation of triphenylmethanol using a Grignard reagent. COMgBr
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This note was uploaded on 11/25/2011 for the course CHEM 52705 taught by Professor Santon during the Spring '11 term at University of Texas.

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grignardreaction-091103134817-phpapp01 - Grignard Reaction...

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