RADD 2501 Class Notes - How Radiation Affects Cells

RADD 2501 Class Notes - How Radiation Affects Cells -...

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1 How radiation affects cells
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2 Ionization The total removal of an electron from an atom.
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3 How ionizations affect cells Directly on cellular component molecules may result in DNA breaks Indirectly on water molecules, causing water derived radicals results in breakage of chemical bonds of the affected molecules
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4 DNA Damage DNA consists of a pair of complementary double strands Breaks of either one or both strands can occur
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5 Single strand breaks can be repaired normally the two strands complement each other, so that the intact strand serves as a template for repair of the damaged
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Unformatted text preview: opposite strand 6 Double strand breaks: repair is more difficult ■ Erroneous rejoining of broken ends may occur – maybe induce • mutations • chromosome aberrations • cell death 7 High LET radiations Vs Low LET radiations ■ Dose: # of ionizations per cell ■ For the same dose: ■ Localized DNA damage caused by dense ioinzations by high LET radiations is more difficult repair ■ x-rays are low LET radiations which deposit energy sparsely within cells causing more single strand breaks that are easier to repair...
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RADD 2501 Class Notes - How Radiation Affects Cells -...

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