RADD 2501 Class Notes - LNT Vs Hormesis

RADD 2501 Class Notes - LNT Vs Hormesis - Average: 200...

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1 LNT Vs Hormesis
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2 LNT: any dose, no matter how small, causes risk to exposed persons (adopted by ICRP 1959)
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3 Hormesis i.e. effect in which some chemicals are known, at trace levels, to be necessary and or beneficial to life, but at high levels they are poisonous. adaptive response
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4 Background radiation: Our Own Bodies Typical adult > 9,000 radioactive disintegrations/second that’s >1/2 million/minute striking billions of cells/hour
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5 Natural Background Radiation
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Unformatted text preview: Average: 200 mRad/year in U.S. Range 100 mRad to 50,000 mRad/year worldwide about 2-1,000 DNA damage events each cell/year Radiation to 1 cell enough to initiate cancer? Assumes no defense or repair mechanisms 6 Repair Mechanisms Prevention (antioxidants) DNA repair (enzymes, cell cycle control) Removal of damaged cells (apoptosis, necrosis, differentiation, immune response)...
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RADD 2501 Class Notes - LNT Vs Hormesis - Average: 200...

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