MICR 2537 Autoimmune Disorders Chart

MICR 2537 Autoimmune Disorders Chart - Disease...

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Disease Hyper- sensitivity types involved Antibody: Description SLE Systemic Lupus Erythromatosus II III Anti-nuclear antibody, aka lupus factor; Smith antibody (Sm-antigen) Fever, joint pain; kidney failure, lung inflammation, skin lesions, myocarditis, stroke Rheumatoid arthritis (RA) III IV Rheumatoid factor, aka IgM antibody to IgG Immune complex formation in synovium of joints Post-streptococcal glomerulonephritis III The problem is the immune complex, not the antibody per se. Can be due to different Abs. Damage to glomerulus results in leakage of cells and blood proteins into tubular filtrate. Acute or chronic. Multiple Sclerosis (MS) II IV Antibodies to myelin basic protein, a component of the myelin sheath, during chronic phase Acute: T cells cause reversible lesions in CNS tissue. Chronic: B cells produce antibody that leads to destruction of myelin Insulin-dependent diabetes mellitus (IDDM) II IV Antibodies to pancreatic beta cells that produce insulin Damage to islets of Langerhans by T cells
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MICR 2537 Autoimmune Disorders Chart - Disease...

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