ANAT 2646 Limbic System - LIMBIC SYSTEM MOOD EMOTION...

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LIMBIC SYSTEM MOOD EMOTION AFFECTIVE BEHAVIOR MEMORY Autism - deficit in limbic system
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Limbic system Parahippocampus Cingulate gyrus entorhinal cortex Hippocampal formation hippocampus proper (pyramidal cells) subiculum dentate gryrus (granule cells) fimbria
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Connections Perforant Pathways entorhinal cortex to dentate gyrus alvear pathway Fimbria then fornix Mossy fibers (granule cell axons) to CA3 Pyramidal cells of CA3 to fimbria schaffer collaterals to CA1
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Efferent Connections Entorhinal Cortex to association cortex Fornix
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Afferent Connections Septal Nucleus Cholinergic Locus ceruleus noradrenergic Raphe nucleus 5-HT (depression) Ventral tegmental area dopaminergic (schizophrenia)
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Memory Types Declarative (facts) Procedural (skills) Long Term Potentiation preservation of memory plasticity Anterograde amnesia Ach blockade increased Ach transmission
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Papez’s circuit Emotion
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Basal Forebrain Consolidates memory “wake” state prolongs responsiveness of cortical neurons
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Unformatted text preview: Septal Area • Pleasure center • Afferents – amygdala – olfactory tract – hippocampus – brainstem Septal Area • Efferents – hypothalamus – brainstem – hippocampus Septal Area Functions • Reward area • Memory – cholinergic supply to hippocampus • slow wave activity of hippocampus Cingulate gyrus • Receives input from intralaminar thalamic nuclei – responds to pain • connection with amygdala and insula • connection with amygdala and orbitofrontal cortex • connection with ventral striatum, putamen, and supplemental motor area Amygdala • Dorsomedial – afferents from olfactory cortex • Ventrolateral – afferents from visual, auditory, hippocampus, and somatosensory cortex • Both the DM and VL portions of the amygdala are involved with defense/attack postures Amygdala • Central functions – posture (instinctive) – cognitive – endocrine – modulation of the reticulare formation...
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  • Winter '11
  • RonaldG.Mayne
  • Neuroanatomy, entorhinal cortex, septal area

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