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Unformatted text preview: AUTOIMMUNE DISEASES are characterized by the abnormality of the immune system and production of autoantibodies ("autoaggression") to different components of the connective tissue. Because the connective tissue is in the body everywhere (like the "skeleton" for the tissues and organs) virtually every organ and system may be involved in the pathological process. Systemic lupus erythematosus . • is associated with production of autoantibodies against components of the cell nuclei ( antinuclear antibodies- ANA). • there are two types of antibodies which are considered the pathognomonic for SLE: ANA against double-stranded DNA and against Smith-antigen (Sm- antigen). • the disease develops predominately in the girls in adolescence and young ladies. • virtually all the systems and organs may be involved in the pathological process, but the most involved organs are:- kidneys (lupus-nephritis with prompt development of renal failure);- lungs (lupus-pneumonitis);- cerebral vessels (may results in stroke);...
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This note was uploaded on 11/23/2011 for the course PATH 2541 taught by Professor Ronaldg.mayne during the Winter '11 term at Life Chiropractic College West.
- Winter '11