PATH 2541 Class Notes Part II - For Final

PATH 2541 Class Notes Part II - For Final - NEOPLASIA...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
NEOPLASIA -means “tissue formation” -involves the overgrowth of a tissue to form a neoplastic mass or neoplasm…aka: tumor -the improper production of cells -neoplasm=tumor=cancer -you will see normal and pleomorphic cells in neoplasia -Neoplasia is widespread and potentially grave abnormality whose more serious form is known as cancer. -Cancer occupies number one cause of death in the Unites States and civilized countries. DISORDERS OF TISSUE GROWTH Neoplasia -new tissue formation associated with overgrowth of tissue. -This new formed tissue is called neoplastic mass or tumor. -reversible Hypertrophy -enlargement of a tissue or organ in response to increased demands. -reversible Example : Myocardial hypertrophy- -enlargement of the heart muscle in response to muscle overload. -hypertrophy->hypertension->thickening of walls of heart Atrophy -shrinkage of a cell or reduction organ size. -reversible Hyperplasia -mitosis produces new cells, but only in quantities needed to meet a particular demand. They are needed to perform a function. -increased production of new cells in amounts needed to meet the particular demands. -has norm. size cells….but, too many -reversible Examples : - proliferation of glandular epithelium of the female breast during pregnancy; - restoration of liver mass after liver resection. - Lymph node enlg. Due to hyperplasia of lymph nodes - Bunions - Area of skin where there is inc. irritation such as the soles of your feet seen w/ rheumatoid arthritis.
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
-change of cell type. -This is more serious condition, which could in some situations predispose to development of cancer. -has diff. size norm. cells -reversible Examples : - replacement of columnar bronchial epithelial cells by stratified squamous epithelium in heavy smokers; - replacement of the stomach columnar epithelial cells by intestinal type epithelial cells in chronic gastritis. Dysplasia -loss in the uniformity of the individual cells as well as a loss of their architectural orientation. It represents more advanced changes and is characterized by presence of pleomorphism . -has abnormal and normal cells Pleomorphism is associated with: - variability of the cell shape and size; (in contrast to the regularity of cell structure see in norm. tissue) - larger, more darkly stained nuclei; - increased mitosis rate. **Although both metaplasia and dysplasia are reversible conditions the latter is less reversible and may be considered as precancerous state. Neoplasia -uncontrolled growth of the tissue beyond normal anatomical boundaries due to irreversible alteration of cell growth pattern. (absence of control of cell division) -all cells are pleomorphic -irreversible Aplasia -lack of organ development. Hypoplasia
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

Page1 / 25

PATH 2541 Class Notes Part II - For Final - NEOPLASIA...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online