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RADD 2711 Metabolic Diseases - Hyperparathyroidism

RADD 2711 Metabolic Diseases - Hyperparathyroidism -...

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Unformatted text preview: HYPERPARATHYROIDISM (HPT) 1., Is a generalized term indicating an increase level of parathyroid hormone in the blood 2. Is divided into three types: - Primary HPT ~ characterized by increased secretion of parathyroid hormone as result of abnormality in one or more of the glands, associated with persistent hypercalcemia — Secondary HPT — associated with abnormal stimulation by sustained hypocalcemia usually resulting from chronic renal failure or occasionally GI malabsorption, serum calcium levels are low normal, low and serum phosphorus is elevated .. Tertiary HPT —- in patients with chronic renal failure or malabsorption and long—standing secondary HPT whose parathyroid function becomes autonomous, can also be related to ectopic tissue, can be associated with hypercalcemia 3. Functions of parathyroid hormone: i» direct effect on bone by mobilizing calcium from skeleton ~ effect on kidney stimulating the absorption of calcium (conservation) and inhibition of phosphate resorption -- indirect effect on the intestines influencing the rate of calcium absorption CALCITON IN Is secreted by the human thyroid gland and is controlled by the circulating levels of calcium. Calcitonin inhibits bone resorption; however, the importance of calcitonin as a regulator of calcium metabolism in humans is not clear at present” ...
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