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RADD 2711 Review of Metabolic Bone Disease

RADD 2711 Review of Metabolic Bone Disease - RADD 3204...

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Unformatted text preview: RADD 3204 Skeletal Radiology I REVIEW OF METABOLIC BONE DISEASE l . 2. s 7 8 Osteoporosis: reduced bone mass of normal quality; related to imbalance between osteoclastic and osteoblastic activity favoring osteoclastic resorption; serum calcium, phosphorus and alkaline phosphatase typically normal; generalized osteopenia with fractures frequent Osteomalacia/Rickets: related to deficiency of calcium, vitamin D or phosphorus with multitude of causes including dietary deficiency, malabsorption, liver disease and renal disease; abundance of nnmineralized osteoid resulting in bone softening disease and osteopenia including pseudotracttires; rickets in the child With radiographic findings including loss of zone of provisional calcification , l‘lypophosphatemia: renal disease acquired or genetic resulting in Ph deficiency and leading to osteomalacia/rickets (vitamin D resistant osteomalacia/rickets) lilyperparathyroidism: Primary ~ related to parathyroid tumor or hyperplasia Secondary related to renal disease or GI malahsorption Tertiary ~ related to ectopic autonomous functioning tissue or chronic secondary HPT Radiographic findings related to increased osteoclastic activity with localized resorption including subperiosteal at middle phalanges pathognornonic . Hypoparathyroidism: acquired related to accidental removal/damage to parathyroid glands during thyroid surgery, radiation, infection, carcinoma; hypocalcemia and hyperphosphatemia; radiographic finding is osteosclerosis as well as caivarial thickening and hypoplastic dentition, may be associated with extensive calcification of spinal ligaments and basal ganglia calcification l Pseudohypoparathyroidism: (PH?) genetic disorder related to end organ resistance to parathyroid hormone with normal parathyroid hormone production; characteristic somatotype of short stature, obesity, round face, brachydactyly, abnormal dentition and mental retardation; radiographic findings similar to hypoparathyroidism; hypocalcernia and hyperphosphatemia . Pseudopscudohypoparathyroidism: (PPHP) genetic disorder similar to PHP and frequently a Li sibling of; is the normal calcium and phosphorus version of PHP; produce and respond to parathyroid hormone; same somatotype and radiographic findings . l’lypophosphatasia: congenital abnormality related to decreased alkaline phosphatase production by osteoblasts resulting in findings similar to rickets; radiolucent metaphyscal detects . Hypovitaminosis C (scurvy): deficiency of vitamin C resulting in decreased ability to produce collagen with inadequate osteoid formation; is a form of osteoporosis; adult form identical to adult osteoporosis; childhood form changes at the bone and are characteristic with proper names ...
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