DIAG 2735 Blood Disorders - Blood Disorders Erythrocytes...

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Erythrocytes Erythrocytes production: Red bone marrow of the following: Vertebrae Ribs Sternum Pelvis Upper ends of humerus and femur Erythrocytes produced in response to erythropoietin 90% of erythropoietin kidneys 10% of erythropoietin liver Hematology Terms Cell Size: Normocytic Microcytic small Macrocytic large Anisocytosis Varied size Cell shape: Pokilocytes Abnormally shaped rbc Spherocytes Sphere shaped rbc Drepanocytes Sickle cells Cell colour: Normochromic Hyperchromic Hypochromic Erythrocyte Disorders Anemia (too few) Polycythemia (too many) Anemia 3 Categories Blood Loss Impaired production Hemolysis (destruction) Symptoms Common to All Anemia's Increased cardiac output Increased respiration rate Chronic fatigue Dyspnea upon exertion Faintness Pallor Vertigo Palpitation Headaches Fever Slight edema Systolic murmurs Weak, bounding pulse Blood Loss Anemia Blood Loss Anemia Acute blood loss May be internal or external Results in hypovolemia (decreased blood volume) Blood volume is restored 1-2 days Once volume is restored HCT and Hb drop Red blood cells return to normal in 3-6 weeks Acute Blood Loss Anemia Acute blood loss anemia: Decreased platelets Increased neutrophils w/ shift to left Shift to the left means more band cells than the usual 10% Changes in RBC morphology Anisocytosis poikilocytosis Macrocytosis (increased MCV) nucleated RBCs Blood Loss Anemia Chronic blood loss (slow bleeding) Symptoms do not appear until stored Fe is depleted RBC morphology Microcytic Hypochromic Elevated platelets Leukopenia Impaired Production Anemia Impaired Production Anemia Iron Deficiency Anemia Megaloblastic Anemia: Pernicious anemia Folate deficiency anemia Other Renal Insufficiency Immune related Liver disease Endocrine disorders Bone marrow infiltration Iron Deficiency Anemia Results when loss exceeds intake and stored Fe is depleted (see blood loss) Most common cause of anemia Average adult male has 3-4 year supply stored May result from increased need Example - Growth spurt Most common anemia in infants and toddlers Starts age 6 months when fetal Fe is depleted Called milk anemia from lack of Fe rich food Other causes Partial or total gastrectomy No gastrin therefore absorption is impaired Sprue (malabsorption syndromes of gut) Nontropical - autoimmune Tropical - parasite or vitamin deficiency induced Other causes: Ulcer treatment??? Repeated hemorrhage
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This note was uploaded on 11/23/2011 for the course DIAG 2735 taught by Professor Josephr.forese during the Winter '11 term at Life Chiropractic College West.

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DIAG 2735 Blood Disorders - Blood Disorders Erythrocytes...

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