DIAG 2735 Exam 2 Review #2

DIAG 2735 Exam 2 Review #2 - TEST 2 MATERIAL Basics of RBCs...

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Hematopoeitic Stem Cells Proerythroblast RBC’s Tissue TEST 2 MATERIAL Basics of RBC’s Cytosis- cell size -anisocytosis- variable in size Cytes- cell shape Poikilocytes- irregular Spherocytes- globular Drepanocytes- (aka sickle cell) Reticulocytes- juvenile RBC (released after 24hrs in bone marrow) Chromic- cell color Pleuropotential cells- pre-cell that can differentiate into RBC,WBC, Platelets Cytokines- control cell differentiation of pleuropotential cells B12 & Folic acid -important for maturity of RBC -required for DNA Synthesis (of rapid producing cells) -w/out they lyse Increased Neutrophils w/ shift to LEFT- (immature cells banded together, part of inflammatory process Hemolysis of RBC’s outside the Spleen = Urobilinogen in Urine O2 Erythropoietin (from Kidney)
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A) Acute Blood Loss Anemia PP - accident or internal hemorrhage Blood Test -Normochromic -Poikilocytosis -Macrocytosis -Nucleated RBC’s -Anisocytosis -Reticulocytes (may develop Macrocytes 3-5 days later) platlets WBC’s neutrophils w/ shift to left B) Chronic Blood Loss Anemia PP - slow internal bleeding (not noticed till iron depleted) Blood Test -Microcytic -Hypochromic platelets - Leucopenia 1. IRON DEFICIENT ANEMIA *** most common cause of anemia PP - 1. Currently Pregnant or Young child going through a grow spur 2. PICA (cravings for non-food, ex. Eating clay) S&S - Paresthesia - Burning Tongue - Angular Stomatitis (cracking mouth in corners) - Gastritis - Dysphagia - Spooning Nails Blood Test MCV MCHC HCT ( hematocrit) -Microcytic -Normal WBC -Hypochromic -Anisocytosis -Poikilocytes
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Iron Depletion - infants & children (rapid growth spurt) - pregnancy - stomach or ulcer –ectomy (no acid to absorb) 3 Stages of Iron Deficient Anemia 1) Iron Depletion -( LOSS EXCEEDS INTAKE) -mobilized iron storage ( storage) 2) Iron Deficient Erythropoeisis -( Serum Feritans ) -saturated transfuren (<15%) 3) Iron Deficient Anemia - see Blood Test above - PICA (craving non-foods) ex. (person eating clay) 2. Megaloblastic Anemia 2 types: 1) [Pernicious Anemia] 2) [Folate Deficient Anemia] 1) Pernicious Anemia PP -numbness & tinglings in distal x-tremity -difficulty walking -episodic abdominal pain -gastroectomy -A vegan -Tapeworm present in intestine
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S&S -atrophic glossitis (sore, pale, raw) -episodic abdominal pain ***MC Loss (Vibratory Sensations) (Pallesthesia) -UMNL signs (Paresthesia) - posterior column ( pins & needles in distal x-tremity)(loss of balance) - lateral column (weakness, spastic, DTR) Blood Test MCV Hematocrit -Normochromic (normal iron, Problem w/ DNA Synthesis) -Macrocytic -Poikilocytes -Ovalcytes -Phlimsy RBC memb. B12
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DIAG 2735 Exam 2 Review #2 - TEST 2 MATERIAL Basics of RBCs...

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