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Wk 2 Kidney_Function - Kidney Function Overview Slide 12 of...

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Kidney Function Overview
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Slide 12 of 54
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Urinary System 2 kidneys 2 ureters connecting the kidneys to the bladder urinary bladder urethra
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Kidneys Usually found at the level of T12 to L3 Approximately the size of your fist Right slightly lower because of liver Retroperitoneal Adrenals onto
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Regulates the production of red blood cells – secretes erythropoietin Control the characteristics of body fluids: Volume and composition Excretes waste products Blood pressure Osmolarity Acid/base balance Metabolism Functions of the kidneys
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Functions of the Kidney Function of the kidney is achieved by: Excretion of metabolic end products (wastes) Reabsorption of necessary elements
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Renal Pain Where does renal pain show-up? Homework Give three differential diagnosis for flank pain
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Kidney Functional Unit The nephron Functional unit of the kidney Total 2.4 million Approximately 1 million per kidney Each nephron is capable of forming urine by itself
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Nephron Number of nephrons is constant from birth Loose a nephron and it does not grow back Problem????
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Nephron Components: Renal corpuscle Long tube
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Nephron Basic function of nephron: Clean or clear the blood plasma of unwanted substances and excess electrolytes
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Plasma Non-cellular component of blood Extracellular fluid that communicates with intracellular fluid through capillary pores
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Parts of the Nephron Glomerulus Bowman’s capsule Proximal convoluted tubule Descending Loop of Henle Thin ascending Loop of Henle Thick ascending Loop of Henle Distal convoluted tubule Cortical collecting tubule Collecting duct
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Renal Corpuscle Components: Glomerulus Capillary network Glomerular (Bowman’s) capsule Double-walled epithelium cup that surrounds the glomerulus
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Slide 23 of 54
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Glomerular Capillaries Glomerular capillaries are 100-500 times more permeable than usual capillaries
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Glomerular Capillaries Filter approximately 180 L/day 1-1.5L becomes urine
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Layers of Glomerular Capillary Endothelial layer fenestrae Basement membrane Proteoglycan layer Epithelial layer Podocytes (slit pores)
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Endothelial Layer Endothelial layer has spaces between the cells, called the fenestrae Provide little resistance as a filter Only prevent blood cells from passing through
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