Wk 5 Blood_Indicies - Hematology Hematology Testing...

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Hematology Hematology Testing Coagulation Testing
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Hematology Tests White cell count White cell differential Red cell count Hematocrit Hemoglobin Indices MCV MCH MCHC Sed. Rate Methemoglobin Iron and TIBC RBC morphology Platelet count
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Coagulation Tests Bleeding time Prothrombin time INR Activated clotting time Plasma thrombin time Plasma fibrinogen Fibrin split products
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White Cell Count Total number of WBCs (estimated) Performed by machine 3.9-11.4 thousand/ml Diagnostic for infection, inflammation, or to monitor chemotherapy or radiation therapy Increased = leukocytosis Decreased = leukopenia
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White Cell Differential Provides % of circulating white blood cells Normal values Neutrophils = 55% Lymphocytes = 35% Monocytes = up to 8% Eosinophils = 1-4% Basophils = 0-1%
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Neutrophils Increased levels Neutrophilia Leukocytosis Infection (bacterial) Staph or Strep Inflammatory disease Decreased levels Neutropenia Marrow depression Aplastic anemia Overexposure to x-rays Viral infection Autoimmune disorders
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Neutrophils Typical Mature Neutrophils: Nucleus separated into lobes (2-5 lobes) with a narrow band of chromatin connecting them (segmentation) 3 lobes is average Twice the size of a rbc Light pink cytoplasm Light pink to bluish granules
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Neutrophils Immature neutrophils: Nucleus has not segmented yet Nucleus is a band (banded)
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Immature Neutrophil
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Mature Neutrophils
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Mature Neutrophils
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Eosinophils Increased levels Allergic reaction Type I hypersensitivity Parasitic infection (round worm) flukes, roundworm, nematode, trichenella Skin disease (psoriasis) Neoplastic diseases Cancer, tumors Low levels Stress Cushing’s
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Eosinophils Typical Appearance: Banded or bilobed nucleus Granules are uniform size Brick red color when stained with eosin
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Eosinophils
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Basophils Increased levels Chronic myelocytic leukemia (CML) Ulcerative colitis Chronic hypersensitivity (allergy) Granules are histamine and heparin
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Typical Appearance: Round, indented, band, or lobulated nucleus (usually binucleated)
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Wk 5 Blood_Indicies - Hematology Hematology Testing...

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