DIAG 2735 Summary of GMN - microscopy Goodpasture Syndrome...

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Summary of GMN Several different types
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Multiple myoloma Why do I care? Presents with Back Pain!!!!! Monoclonal Gamopathy Will cause monoclonal spike on elctrophoresis. Why? Lytic lesions in spine due to? What does this have to do with the kidney?
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Multiple myoloma Monoclonal spike caused by proliferation of plasma cells into gamma globulins, Igg, Iga, ect but only ONE!! Hyper proliferation of cells causes suppression of osteoblasts. Hyper proliferation of cells causes a deposit of Ig’s in the basement membrane causing a malfunction in the permeability of light chains =Bense Jones proteinuria.
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Post Streptococcal Post streptococcal Acute Antibody mediated You will see diffuse proliferation on light microscopy Sub epithelial humps on electron
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Unformatted text preview: microscopy Goodpasture Syndrome Auto immune condition clinically shows with repeated lung and kidney infections Rapidly progressive GMN Anti GBM You will see proliferation crescents on light microscopy and GBM disruptions on electron microscopy Minimal change Disease A Nephrotic syndrome Unknown pathogenesis Most common in children Light microscopy NORMAL Electron microscopy shows loss of foot processes, no deposits Nephritic Vs. . Nephrotic Nephritic=RBC cast in specimen Mild to moderate proteinuria/less 3.0 grams No pitting edema or acites Nephrotic= fatty cast in specimen 3.5 or more grams of protein Pitting edema...
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This note was uploaded on 11/23/2011 for the course DIAG 2735 taught by Professor Josephr.forese during the Winter '11 term at Life Chiropractic College West.

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DIAG 2735 Summary of GMN - microscopy Goodpasture Syndrome...

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