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DIAG 2735 Summary of GMN - microscopy Goodpasture Syndrome...

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Summary of GMN Several different types
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Multiple myoloma • Why do I care? • Presents with Back Pain!!!!! • Monoclonal Gamopathy • Will cause monoclonal spike on elctrophoresis. Why? • Lytic lesions in spine due to? • What does this have to do with the kidney?
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Multiple myoloma • Monoclonal spike caused by proliferation of plasma cells into gamma globulins, • Igg, Iga, ect but only ONE!! • Hyper proliferation of cells causes suppression of osteoblasts. • Hyper proliferation of cells causes a deposit of Ig’s in the basement membrane causing a malfunction in the permeability of light chains =Bense Jones proteinuria.
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Post Streptococcal • Post streptococcal • Acute • Antibody mediated • You will see diffuse proliferation on light microscopy • Sub epithelial humps on electron
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Unformatted text preview: microscopy Goodpasture Syndrome • Auto immune condition clinically shows with repeated lung and kidney infections • Rapidly progressive GMN • Anti –GBM • You will see proliferation crescents on light microscopy and GBM disruptions on electron microscopy Minimal change Disease • A Nephrotic syndrome • Unknown pathogenesis • Most common in children • Light microscopy NORMAL • Electron microscopy shows loss of foot processes, no deposits Nephritic Vs. . Nephrotic • Nephritic=RBC cast in specimen • Mild to moderate proteinuria/less 3.0 grams • No pitting edema or acites • Nephrotic= fatty cast in specimen • 3.5 or more grams of protein • Pitting edema...
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  • Winter '11
  • JosephR.Forese
  • nephrotic syndrome, Minimal change disease, Hyper proliferation, monoclonal spike, Multiple myoloma
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