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Unformatted text preview: blood circulation, immune response produces antibodies ( outside kidneys ), leads to vasculitis) 2. Anti-GBM (Glomerular Basement Membrane) a. Basement membrane is considered foreign by the immune system, leads to production of antibodies that destroy GBM, Type II hypersensitive reaction Antibody mediated 3. Heymann a. Attack on the antibodies by the visceral epithelial cells (podocytes) Juxtaglomerular cells sense pressure on afferent arteriole, produce/release Renin and it leads to an increase in BP Podocytes (visceral epithelial cells) have filtration slits and filtrate the primary urine Parietal epithelial cells Nephritic syndrome Is manifested clinically by:- Hematuria (with red blood casts)- Azotemia – biochemical abnormality that refers to the elevated levels of blood urea nitrogen and creatinine which is associated with reduced GFR-Uremia – is a clinical sign, patient feels it-Hypertension...
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This note was uploaded on 11/23/2011 for the course PATH 2542 taught by Professor Markamos during the Winter '11 term at Life Chiropractic College West.
- Winter '11