PATH 2542 Lab Notes 2 - 2 3 Nephrotic Syndrome-any systemic...

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2 Nephrotic Syndrome-any systemic disease of the kidney o Condition where glomeruli become leaky o Not a disease itself, it results from some other condition ie. Diabetes or SLE o 4 conditions: hyperlipidemia, hypercholesteria, hyperproteinuria, edema 3 Nephritis: Post streptococcal (Group A Beta hemolytic Strep) High ASO o Clinical Manefestations = PHAROH Proteinuria Hematuria Azotemia Red Blood Cell Casts Oliguria Hypertension WBC’s in urinalysis, flank pain, UTI (e. coli-most common, proteus- from hospitalization)-mostly females because of anatomy, chills/fever, hydronephrosis=backflow kidney infection Diseases of the Glomeruli Minimal Change Disease-Liepoid Nephrosis -most common in 2-6 year olds/deposits of lipids in basement membrane epithelial foot processes(podocytes) fuse together Proximal convoluted tubule Glomerulosclerosis -can be focal(any part of kidney at any point) or segmental(one part at one time), most common in older patients, sclerosis of the capillary in the juxtaglomeruli Membrano-glomerulo-nephritis -most common in teenagers, primary cause of N.S., thicker capillary walls, deposits of Ig3 and C3, will see spike and dome appearance under immunoflourescense, (SLE, malignancies, Hep. B, Syphilis, malaria Good Pasture’s Disease -affects the kidney and the lung, auto immune disease (type 3 hypersensitivity), IgG in abundance, immune complex attaches to basement membrane of alveoli and/or the glomeruli IgA Nephropathy (Berger’s Disease)- researched in Germany, 1. massive IgA deposits that block the filtration of the glomeruli, 2. Recurrent Hematuria- blood in the urine lasting only a few days Alports Disease - Hereditary Nephritis with Deafness Urolithiasis -most commonly Ca Oxalate(from milk, tomatoes, Vit C or hyperparathyroidism), uric acid(gout) Diabetic Nephropathy -causes diffuse and nodular glomerulosclerosis (nodular=Kimmelstein Wilson nodes), comes with renal failure and proteinuria Amyloidosis -amyloid deposits, hematuria, uremia
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Tubule Diseases (3) Acute Drug Induced Interstitial Disorder -from nephrotoxic drugs (Ibuprophen, NSAIDS), can have complete recovery Renal Papillary Necrosis -caused by ischemia/NSAIDS/post acute pyelonephritis, diabetes will have history of this Acute Tubular Necrosis -caused by anything that can cause renal failure, hemorrhage, hypovolemia, can lead to death, septicemia, chronic dehydration Renal Tubular Function (4) Franconi Disease -generalized dysfunction of proximal tubule, impaired resorption of glucose, AA’s, phosphate, Bicarbonate, manifested by glycouria, hyperphosphatemia,
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PATH 2542 Lab Notes 2 - 2 3 Nephrotic Syndrome-any systemic...

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