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BIBC 102 Exam 1 Fall 11 KEY

BIBC 102 Exam 1 Fall 11 KEY - KEY BIBC 102 Metabolic...

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BIBC 102 Metabolic Biochemistry KEY Fall Quarter 2011 Midterm Exam (400 pts.) MWF Lecture Part 1—Do this part of the exam first: 1) (4 pts. each) Which of the following are affected (changed) by the catalytic activity of enzymes? ( Check all that apply ) a. ΔG’°____ b. ΔG° X c. The rate constant for the reaction X d. The standard free energy of activation for the reaction X e. The equilibrium constant for the reaction ____ f. The overall thermodynamic favorability of the reaction ____ g. The rate at which the reaction reaches equilibrium X 2) (10 pts.) During glycolysis, the enzyme aldolase splits fructose 1,6-bisphosphate into glyceraldehyde 3-phosphate (G3P) and dihydroxyacetone phosphate (DHAP). When this reaction is allowed to proceed to equilibrium in vitro (in a test tube) the following concentrations of each compound are found: Fructose 1,6-P: 3.0 mM G3P: 0.9 mM DHAP 3 mM What is the equilibrium constant for this reaction? (Show your work) Convert to molar concentration K eq = (9 x10 -4 M)(0.003 M) = 9 x10 -4 M 0.003 M Units not required; 5 pts. for correct set up, 5 pts. for correct answer 3) (12 pts.) Based on the equilibrium constant you calculated for question 2, calculate ΔG’° for the conversion of fructose 1,6 bisphosphate to G3P and DHAP. (Show your work) G°’ = -RT ln K eq 4 pts. G°’ = -(8.315 J/mol•K)(310 K)( ln 9 x10 -4 ) 4 pts. G°’ = (-2.578 kJ/mol)(-7.0) = 18 kJ/mol 4 pts.
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