CH14-1

CH14-1 - Chapter 14, Part I Chromosomal Rearrangements...

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Chapter 14, Part I Chromosomal Rearrangements Assignment Chapter 14 problems: 29, 30, 35, 36
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Outline of Chapter 14 Chromosomal Rearrangements Deletions Duplications Inversions Translocations Changes in chromosome number Aneuploidy Monoploidy Polyploidy
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Mouse chromosome 1 contains large blocks of DNA found on 7 human chromosomes
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Chromosomal Rearrangements Deletions Duplications Inversions Translocations Arise from: 1) Replication errors 2) Recombination errors 3) Damaging agents (e.g. X-rays)
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Deletions remove genetic material from genome Homozygous mostly lethal Heterozygous usually has no phenotype (if small; i.e. a few genes) large deletions can be lethal Why? Genetic imbalance (dosage effect)
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Deletions can “uncover” genes Hemizygous = only 1 copy of an allele Red (st + /st + or st + /st) Scarlet (st/Del) Pseudodominance : appearance of a recessive phenotype due to the absence of an allele
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Duplications add material to the genome Tandem vs. nontandem (i.e. dispersed)
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Are duplications more or less likely to cause a phenotype than a deletion of comparable size?
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This note was uploaded on 11/27/2011 for the course BIOL 12 taught by Professor Kim during the Spring '10 term at LSU.

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CH14-1 - Chapter 14, Part I Chromosomal Rearrangements...

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