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1700840127_ftp - U . S ANDBANK 228 SU Y A new-born infant...

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228 U. SANDBANK SU-Y A new-born infant died 24 hours after a normal delivery as a result of intracerebral hemorrhage. Post-mortem examination revealed an astrocytoma of the left basal ganglia. Eleven other neonatal gliomata have been collected from the literature. I would like to thank Dr E. Liban. Head, Department of Pathology. for his interest and advice and Mr R. Dor for the photographs. REFERENCES ARNSTEIN, L. H., BOLDREY, E., 1951. J. Neuroeurg., 8, 316. BODIAN, M.. AND LAWSON, D. . 1962-63. Bd. J. Sum., 40, 368. AND NAFBZIQER, H. C. .. CANAVAN, MYRTELLE M., Cusma, H. . . . . . . . HEMS AT^, F. A. DESAUSSURE, R. L., MILLER, J. H., DRUCKER, G. A. . . . . . ENDE, N. . . . . . . . GLOBUS, ZUCKER, J. M., GREENHOUSE. A. H., AND NEU- GROSS, S. W. . . . . . . MATSON, D. D. . . . . . . RUSSELL, DOROTHY S., ELLIS, STRICKLAND, C. E. RUBINSTEIN, J. M. BUEROER, K. T. R. W. B. SAPIN, s. . . . . . . . SCHATZKI, P. F., MORTATI, C., YVOBODA, D. J. . . . . . . AND MCCAIN, W. G. THLELE, R. L., DmnmIcrc, MuRmL J. WELLS, H. G. . . . . . . WOLLSTEIN, MARTHA, BARTLETT, F. H. 1931. 1932. 1960. 1939. 1955. 1943. 1960. 1934. 1953. 1933. 1952. 1956. 1959. 1951. 1940. 1923. Arch. Neu& Phchiat., 26, 1234. Intracrmial tumors, Sprinafiew, Sub. Med. J. (Bgham, Ah.), 53, Arch. Path., 28, 390. Cancer, Philad., 8, 1057. Amer. J. Ms. Child., 65, 604. IU., p. 102. 918. Arch. Neurol. . 3. 718. Amer. J. Die. Child. . 48, 739. J. Neuroaurg., 10, 416. Arch. Dis. Childh., 8. 329. J. Pediatr., 40, 781. New Engl. J. Med., 255, 908. J. Neurvpath. Exp. hrezirol. . 18, 39, 611. Arch. Path., 30, 535. Amer. J. Dis. Child., 25, 257. 569. TRA4NSDURAL SPREAD OF GLIOBLASTOMA MULTIFORME N. G. SAKERKIN Department of Pathology. University of Bristol (PLATES LI LII) Resistance of dense fibrous tissues to infiltration by malignant tumours is well recognised (Willis, 1952), and the dura provides an excellent example of a dense collagonous capsule forming a complete envelope for the central nervous system. Willis (1962) states that metastatic growths in the contiguous bones may invade the dura mater, but that it is rare for thein to penetrate it. . The same
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J. PATH. RAW.-VOL. 81 TRANSDURAL SPREAD OF GLIOBLASTOMA PLATE I,I FIG. 1.-Typical field from upper parts of FIG. 2.-Typical field from lower parts tumour : cytoplasmic and nuclear pleo- tumour with predominantly spindle-shaped morphisrn, with giant and multinucleate cells ; numerous mitoses are present. H. cells. Hzematoxylin and eosin. x 450. andE. X450. FIG. 5.-Tumour infiltrating narrow spaces skull base, with osteoclaatic resorption of osseous trabeculre. Masson’s blue trichrome. X 110.
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TRANSDURAL SPREAD OF QLIOBLASTOi%fA 229 is true of metastatic deposits on the surface of the brain, which often become adherent to the dura without actually penet.rating it. Resistance of the dura to penetration by gliomas is similarly recognised (Rwsell and Rubinstein, 1959, p. 151). Although firm union is often seen between malignant glial tumours and the diwa, microscopical examination shows that the inner layer alone is infiltrated. Penetration of the dura, with subsequent direct spread into extra- dural t,issues or invasion of a dural sinus, would appear to be a prerequisite for extraneural dissemination of gliomas, for no example of remote metastasis has bean recorded in which the dural barrier remained inviolate. In discussing the extracranial dissemination of gliomas, and the factors involved in such dis-
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This note was uploaded on 11/28/2011 for the course BME 100 taught by Professor Dr.frame during the Spring '11 term at SUNY Stony Brook.

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1700840127_ftp - U . S ANDBANK 228 SU Y A new-born infant...

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