DNA1 - EmergingTechnologiesof Computation MontekSingh...

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Emerging Technologies of  Computation Montek Singh COMP790-084 Nov 15, 2011
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Two different technologies TODAY:   DNA as biochemical computer DNA molecules encode data enzymes, probes etc. manipulate data Thurs:   DNA used to assemble electronic computer DNA molecules used as scaffolding nanoscale electronic components piggyback DNA assembles the computer Today:  Computing using DNA
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“I was fascinated.  With my own hands, I was  creating DNA that did not exist in nature.” Leonard M. Adleman Scientific American, August 1998
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What is a DNA computer? A system that manipulates DNA to solve mathematical  problems How is information represented? In DNA molecules How is information manipulated? Using enzymes and ligases How do you obtain gain/amplification? DNA replication How do you read output? Computing with DNA
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4 types of molecular building blocks Adenine, Thymine, Guanine, Cytosine Shortened to 4 symbols:  A, T, G, C Double-helix structure complementary strands A and T bond with each other G and C bond with each other Basics of DNA
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Watson-Crick pairing each strand has its complement the two will “anneal” (twist around each other) weak hydrogen bonds break easily with heat non-complementary strands will not anneal Basics of DNA
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Polymerases copy information from a strand template, make its complement
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This note was uploaded on 11/28/2011 for the course COMP 790 taught by Professor Staff during the Fall '08 term at UNC.

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DNA1 - EmergingTechnologiesof Computation MontekSingh...

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