Science-2006-Cowburn-183-4 - Where Have All the Transistors...

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DOI: 10.1126/science.1122441 , 183 (2006); 311 Science R. P. Cowburn Where Have All the Transistors Gone? This copy is for your personal, non-commercial use only. clicking here. colleagues, clients, or customers by , you can order high-quality copies for your If you wish to distribute this article to others here. following the guidelines can be obtained by Permission to republish or repurpose articles or portions of articles ): September 6, 2011 (this infomation is current as of The following resources related to this article are available online at version of this article at: including high-resolution figures, can be found in the online Updated information and services, found at: can be related to this article A list of selected additional articles on the Science Web sites , 1 of which can be accessed free: cites 2 articles This article 9 article(s) on the ISI Web of Science cited by This article has been Physics, Applied subject collections: This article appears in the following registered trademark of AAAS. is a Science 2006 by the American Association for the Advancement of Science; all rights reserved. The title Copyright American Association for the Advancement of Science, 1200 New York Avenue NW, Washington, DC 20005. (print ISSN 0036-8075; online ISSN 1095-9203) is published weekly, except the last week in December, by the Science on September 6, 2011 Downloaded from
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transport mechanisms. Determining precisely which characteristics of a cage structure drive this choice should prove interesting. Whatever the answers to these questions, Stagg et al . provide us with an intriguing new structure that, like clathrin, helps cells solve the problem of forming capsules of varying size while precisely controlling their forma- tion and contents. Further cryo–electron microscopy maps could tell us the position of other COPII coat components in relation to the cage and, at higher resolutions, define the location of individual Sec13p and Sec31p sub- units, and the nature of the interactions that define lattice assembly. References and Notes 1. S. M. Stagg et al ., Nature 439 , 234 (2006) 2. C. J. Smith, N. Grigorieff, B. M. Pearse, EMBO J. 17 , 4943 (1998). 3. A. Musacchio et al ., Mol. Cell 3 , 761 (1999). 4. A. Fotin et al ., Nature 432 , 573 (2004). 5. L. C. Bickford, E. Mossessova, J. Goldberg, Curr. Opin. Struct. Biol. 14 , 147 (2004). 6. G. Z. Lederkremer et al ., Proc. Natl. Acad. Sci. U.S.A. 98 , 10704 (2001). 7. X. Bi, R. A. Corpina, J. Goldberg,
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Science-2006-Cowburn-183-4 - Where Have All the Transistors...

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