230_020911 (1)

230_020911 (1) - Receptors G protein-coupled receptors...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: Receptors G protein-coupled receptors Largest family and found in all eukaryotes 1000 in mice involved in sense of smell alone Receptor tyrosine kinases Major class possessing intrinsic enzyme activity Coordinate many aspects of cell growth and reproduction involvement in cancer Ion channel receptors Steroid hormone receptors Cytoplasmic proteins that localize to Fig. 11-9 Signaling molecule Receptor Activated relay molecule Inactive protein kinase 1 Active protein kinase 1 Inactive protein kinase 2 ATP ADP Active protein kinase 2 P P PP Inactive protein kinase 3 ATP ADP Active protein kinase 3 P P PP i ATP ADP P Active protein PP P i Inactive protein Cellular response P h o s p h o r y l a t i o n c a s c a d e i Transduction: Phosphorylation cascades Adenylyl cyclase Fig. 11-10 Pyrophosphate P P i ATP cAMP Phosphodiesterase AMP Second Messengers - 1 First messenger Fig. 11-11 G protein Adenylyl cyclase GTP ATP cAMP Second messenger Protein kinase A G protein-coupled receptor Cellular responses EXTRACELLULAR FLUID ATP Nucleus Mitochondrion Ca 2+ pump Plasma membrane CYTOSOL Ca 2+ pump Endoplasmic reticulum (ER) Ca 2+ pump ATP Key High [Ca 2+ ] Low [Ca 2+ ] Second Messengers: 2 (and 3) Fig. 11-13-1 EXTRA- CELLULAR FLUID Signaling molecule (first messenger) G protein GTP G protein-coupled receptor Phospholipase C PIP 2 IP 3 DAG (second messenger) IP 3-gated calcium channel Endoplasmic reticulum (ER) Ca 2+ CYTOSOL Fig. 11-13-2Fig....
View Full Document

Page1 / 24

230_020911 (1) - Receptors G protein-coupled receptors...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online