230_021111 - Cell Cycle and Mitosis Chapter 12 February 11,...

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Cell Cycle and Mitosis Chapter 12 February 11, 2011
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Chapter 12: Cell Cycle Reproduction Growth and development Tissue renewal Amoeba Sand dollar embryo Bone marrow cells
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Cell Cycle: Clock The cell is controlled by a cell cycle much like a clock. Decisions about proliferation and differentiation controlled by signal transduction pathways In eukaryotic organisms: 2 Major Phases Interphase: GI, S and G2 phases Mitosis: 5 stages
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Cell Cycle: Phases of the Clock First Gap Second Gap 90% of time cell is in interphase 10% Mitosis
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Cell Cycle Control System Set of molecules that coordinates cell cycle events. Checkpoints respond to internal and external cues. They can stop or advance to the next phase in the cycle. • Three major checkpoints: G I , G 2 , and M phases. • In animal cells G I acts as “restriction point” - most important. Most cells in the adult body exit the cell cycle, referred to as G 0
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Cell Cycle: Mitotic Phase Five stages Prophase Prometaphase Metaphase Anaphase Telophase The separation of cellular and genetic information into two daughter cells
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Fig. 12-6 G 2 of Interphase Centrosomes (with centriole pairs) Chromatin (duplicated) Nucleolus Nuclear envelope Plasma membrane Early mitotic spindle Aster Centromere Chromosome, consisting of two sister chromatids Prophase Prometaphase Fragments of nuclear envelope Nonkinetochore microtubules Kinetochore Kinetochore microtubule Metaphase Metaphase plate
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This note was uploaded on 11/28/2011 for the course BIOL 230 taught by Professor J.breckler during the Spring '11 term at S.F. State.

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230_021111 - Cell Cycle and Mitosis Chapter 12 February 11,...

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