Lecture_5_Peptides

Lecture_5_Peptides - FORMATION OF A PEPTIDE H H + H CH C H...

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PROTEIN STRUCTURE FORMATION OF A PEPTIDE CH C CH 3 O - O N CH C CH 3 O - O H H H N H H H + CH C CH 3 O N H H H N CH C CH 3 O - O H + Amino Acid Residues VERY LARGE POLYPEPTIDES: PROTEINS proteins are polymers of amino acids the linear sequence (N C) is the primary (1°) structure of the polypeptide. the number of amino acids in a polypeptide can be estimated Avg . MW = 130 Adjusted Avg . MW = 128 Adjusted Avg . MW after loss of water = 110 ± to estimate the number of amino acids in a protein, divide its MW by 110 sequence function structure
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sequence function 3D-PROTEIN STRUCTURE Higher Orders of Structure PROTEIN STRUCTURE The three dimensional structure of a protein is what gives it its function Individual proteins typically have one overall structure that they maintain under a favorable set of conditions PROTEIN STRUCTURE: KEY POINTS TO KEEP IN MIND 1. Amino acid sequence structure MET SER HIS HIS TRP GLY TYR GLY LYS HIS ASN GLY PRO GLU HIS TRP HIS LYS ASP PHE PRO ILE ALA LYS GLY GLU ARG GLN SER PRO VAL ASP ILE ASP THR HIS THR ALA LYS TYR ASP PRO SER LEU LYS PRO LEU SER VAL SER TYR ASP GLN ALA THR SER LEU ARG ILE LEU ASN ASN GLY HIS ALA PHE ASN VAL GLU PHE ASP ASP SER GLN ASP LYS ALA VAL LEU LYS GLY GLY PRO LEU ASP GLY THR TYR ARG LEU ILE GLN PHE HIS PHE HIS TRP GLY SER LEU ASP GLY GLN GLY SER GLU HIS THR VAL ASP LYS LYS LYS TYR ALA ALA GLU LEU HIS LEU VAL HIS TRP ASN THR LYS TYR GLY ASP PHE GLY LYS ALA VAL GLN GLN PRO ASP GLY LEU ALA VAL LEU
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This note was uploaded on 11/28/2011 for the course CHEM 340 taught by Professor T.baird during the Fall '11 term at S.F. State.

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Lecture_5_Peptides - FORMATION OF A PEPTIDE H H + H CH C H...

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