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Lecture_15-Enzymatic_Catalysis

Lecture_15-Enzymatic_Catalysis - Binding energy is used to...

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PROTEIN FUNCTION II: CATALYSIS Introduction Binding energy is used to overcome barriers to chemical reaction Barrier 1: Conformational entropy of substrate ± substrate is held in the proper orientation ± substrate can be precisely aligned ± limiting the motion of two reactants can significantly enhance rates of reaction OR What order reaction is this? A. 1 st B. 2 nd OR What would be the units of the rate constant for this reaction? A. M/s B. M -1 s -1 C. s -1
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OR What order reaction is this? A. 1 st B. 2 nd OR What would be the units of the rate constant for this reaction? A. M/s B. M -1 s -1 C. s -1 Binding energy is used to overcome barriers to chemical reaction Barrier 2: Desolvation E Barrier 3: Distortion Barrier 4: Weakness of interactions
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Weak interactions also account for specificity specificity: the ability to discriminate between a substrate and a competing molecule 2X Catalysis occurs in different ways The mode of catalysis is determined by how the active site residues (and prosthetic groups or cofactors) lower G ±
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