Lecture_15-Enzymatic_Catalysis

Lecture_15-Enzymatic - PROTEIN FUNCTION II CATALYSIS Introduction Binding energy is used to overcome barriers to chemical reaction Barrier 1

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Unformatted text preview: PROTEIN FUNCTION II: CATALYSIS Introduction Binding energy is used to overcome barriers to chemical reaction Barrier 1: Conformational entropy of substrate ¡ substrate is held in the proper orientation ¡ substrate can be precisely aligned ¡ limiting the motion of two reactants can signiFcantly enhance rates of reaction OR What order reaction is this? A. 1 st B. 2 nd OR What would be the units of the rate constant for this reaction? A. M/s B. M-1 s-1 C. s-1 OR What order reaction is this? A. 1 st B. 2 nd OR What would be the units of the rate constant for this reaction? A. M/s B. M-1 s-1 C. s-1 Binding energy is used to overcome barriers to chemical reaction Barrier 2: Desolvation E Barrier 3: Distortion Barrier 4: Weakness of interactions Weak interactions also account for speciFcity specifcity: the ability to discriminate between a substrate and a competing molecule ✔ ✔ ✗ 2X Catalysis occurs in different ways The mode oF catalysis is determined by how the active site residues (and prosthetic groups or coFactors) lower...
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This note was uploaded on 11/28/2011 for the course CHEM 340 taught by Professor T.baird during the Fall '11 term at S.F. State.

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Lecture_15-Enzymatic - PROTEIN FUNCTION II CATALYSIS Introduction Binding energy is used to overcome barriers to chemical reaction Barrier 1

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