Test 2 Review Sheet

Test 2 Review Sheet - Test 2 Review Sheet *This is what I...

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Test 2 Review Sheet *This is what I think is important from the chapters. Dr. Rothschild has not looked at this and it may not be all inclusive of questions that may appear on the test. * At the end of each chapter there is a page called essential concepts: I think these are very helpful in picking out the main ideas of each chapter. I think the book has very good figures to explain certain concepts and I have indicated which figures I think are most helpful/most important. Chapter 4: Protein Structure and Function Like most things in biology form equals function. A protein’s shape is crucial to its function. By knowing the shape its function can also be determined. The shape is due to the sequence of amino acids and their interactions Amino acids are linked by peptide bonds via a condensation reaction. Amino acids chains are polar/ have directionality: N-terminus and C-terminus Amino acid – polypeptide – protein Polypeptide backbone ( what it is and how you make it) The nature of the A.A: Acidic, basic, polar, non polar and how this influences structure Non covalent bonds help proteins fold: know what these bonds, where they form, are and how they help Proteins fold to form the lowest energy level! Hydrophobic interactions: the hydrophobic amino acid residues will shield themselves from water and the hydrophilic ones will be attracted to waster Molecular chaperones help the protein fold into its final conformation Know some of the shapes of proteins Alpha helix and Beta Sheets: what they are, what kind of protein structure they are, where the bonds are, (fig 4.10) o Alpha helix are often found in transmembrane proteins o Coiled coil LEVELS OF ORGANIZATION!: know what each is and what determines them o Primary o Secondary o Tertiary o Quaternary Protein domains Protein subunits (each poly peptide chain) o How subunits link together depends on the number of binding sites Protein families have similar amino acid sequences and thus similar shapes Globular vs Fibrous proteins (general function of each and examples) Disulfide bonds: what they are and how they function in proteins Ligand binding: what is it influenced by Antibodies: what they are, shape (fig 4-29), think about how they are examples of what we know about proteins (structure, function, binding) Know table 4-1 Enzyme Catalysis (4-30 and 4-32) Like everything in the cell, proteins are highly regulated!
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Feedback mechanisms: negative and positive o Can regulate an enzyme by changing its shape: allosteric regulation (4-36) Phosphorylization influences regulation GTP binding can influence activity as can ATP binding
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This note was uploaded on 11/29/2011 for the course BIO 218 taught by Professor Rothschild during the Spring '11 term at VCU.

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Test 2 Review Sheet - Test 2 Review Sheet *This is what I...

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