Chemotherapeutic Drugs-Variant 1

Chemotherapeutic Drugs-Variant 1 - Chemotherapeutic Drugs...

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Chemotherapeutic Drugs Variant # 1 1.Isoniazid is eliminated rapidly in some people but slower in others because: A. Of hereditary variation in the rate of isoniazid excretion by the kidneys B. Of a variable capacity of the hepatic enzyme acetyltransferase to metabolise isoniazid C. Pseudocholinesterase enzymes exhibit a form of polymorphism D. The enzyme glucose-6-phosphate dehydrogenase exists in at least two polymorphic forms E. Isoniazid polymerase is absent in some individuals 2.The sulphonamides act as chemotherapeutic agents because they: A. Intercalate with DNA B. Inhibit RNA synthesis C. Bind to the plasma membrane D. Are structural analogues of p- aminobenzoid acid E. Chelate various metal ions 3.Acyclovir is not: A. Active against herpes simplex type I B. Given orally C. Active against herpes simplex type II D. A purine analogue E. A pyrimidine analogue 4.Basic principles of cancer chemotherapy include the following EXCEPT: A. Intermittent dose schedules are generally followed to restore the drug- induced damage of bone marrow B. Cancers with shorter mass doubling times are less susceptible than those with longer mass doubling time C. Cancerous tissue possessing a small growth fraction is less susceptible than with a larger growth fraction D. Repair of DNA in normal cells is relatively more rapid than in cancer cells E. Optimal dosages are based upon maximum tolerated dose 5.When patients fail to respond to the first-line chemotherapy the likelihood of a response to a second-line regimen may be diminished due to one or more of the following reasons EXCEPT: A. enhanced expression of multidrug resistance gene B. enhanced expression of p53 gene C. decreased performance status of the patient D. increased tumor burden E. selection of resistant clones 6.Which of the following statements is NOT true with respect to chemical carcinogenesis? A. aromatic amines are metabolized by cytochrome P450 enzymes to the N- hydroxy derivatives B. alkylating agents do not require enzymatic activation to interact with DNA C. nitrosamines formed after ingestion of nitrites can then directly interact with DNA D. azo dyes are metabolized by cytochrome P450 enzymes 7.The route by which isoniazid is usually administered is: A). oral B). intramuscular injection of solution C). intramuscular injection of suspension D). subcutaneous injection of solution E). intravenous 8.Most adults who are at high risk of developing pulmonary tuberculosis should be treated with: A). isoniazid 100 mg/day for 6 months B). isoniazid 300 mg/day for 12 months C). ethambutol 400 mg/day for 12 months D). rifampin 600 mg/day for 24 months E). No treatment is necessary 9.Which of the following agents used in the treatment of pulmonary tuberculosis has the side effect of loss of perception of the color green? A). isoniazid
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Chemotherapeutic Drugs-Variant 1 - Chemotherapeutic Drugs...

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