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Unformatted text preview: 125:306 PRACTICE EXAM #2 80 minutes Name : __________________________________________ Question 1 The Scatchard plots below compare the binding of a hormone to the receptors of five abnormal persons (solid line) and a normal person (broken line). Which patient shows the same number of binding sites but lower receptor affinity compared to the normal person? The plots below show the binding isotherm (left) and corresponding Hill plot (right) of oxygen to hemoglobin, which has 4 oxygen binding sites per molecule, as a function of 2,3-diphosphoglycerate (DPG) levels in red blood cells. The concentration of DPG is normally 5 mM, but can go up or down when the body adapts to changes in the environment. Question 2 Given that K = affinity of hemoglobin for oxygen, and n = Hill coefficient, for increasing DPG, which is true: (a) K and n increase (d) K increases, n decreases (g) K increases, n remains the same (b) K decreases, n increases (e) K and n decrease (h) K decreases, n remains the same (c) K remains the same, n increases (f) K remains the same, n decreases (i) K and n remain the same Question 3 Assuming lung pO 2 = 100 torr and tissue pO 2 = 20 torr, what statement below is most correct? (a) Increasing DPG increases the amount of oxygen delivered to the tissue (b) Increasing DPG decreases the amount of oxygen delivered to the tissue (c) Binding of oxygen to hemoglobin is an all or none binding phenomenon (d) None of the above....
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This note was uploaded on 12/01/2011 for the course BME 125:306 taught by Professor Berthiaume during the Spring '11 term at Rutgers.
- Spring '11