HM_neurons - APPROACHES TO THE BIOLOGY OF MEMORY Scale of...

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APPROACHES TO THE BIOLOGY OF MEMORY Scale of analysis: Micro: intra, intercellular Medio: cell assemblies and neural networks Macro: Coordinated brain systems Focus of Analysis: Content : particular memories, “kinds” of memories Process: mechanisms of encoding, persistence, retrieval Goal of analysis: Reductionism : from cognition to biochemistry Cognitive neuroscience : building bridges between levels of discourse
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THE NEURONAL BASES OF MEMORY A (re)view of neuronal conduction Potential memory mechanisms More (or fewer) neurons More (or fewer) synapses Efficiency of synapses Surface area of synapses Changes in other cell areas
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Activation and Alteration of Synapses Kandel’s work with Aplysia (Sea Hare) Habituation of gill-withdrawal reflex Presynaptic membrane is altered Fewer calcium ions Fewer vesicles move to cleft Less neurotransmitter is released Smaller postsynaptic potential shift Smaller motor nerve stimulation Diminished gill withdrawal
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HM_neurons - APPROACHES TO THE BIOLOGY OF MEMORY Scale of...

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