neuropharm - Neuropharmacology The Life of a Typical...

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Neuropharmacology
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Precursors—”building blocks” Synthesis—assembly of precursors into neurotransmitter molecules Transport to presynaptic terminal Storage in presynaptic terminal Release from terminal (exocytosis) Binding to post-synaptic receptor Inactivation diffusion reuptake enzymatic degradation The Life of a Typical Neurotransmitter
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Neurotransmitters Criteria for Identification
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Neurotransmitter Criteria 1. Identity 2. Synthesis Cell has precursors and enzymes necessary for synthesis of n.t.
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Neurotransmitter Criteria 1. Identity 2. Synthesis 3. Release Must be released from terminals; (collect substance from cleft after nerve stimulation)
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Neurotransmitter Criteria 1. Identity 2. Synthesis 3. Release 4. Receptors Cross desensitization between substance and suspected n.t. Blockade of n.t. action by receptor antagonists Applicaton of suspected n.t. mimics action of nerve stimulation
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Neurotransmitter Criteria 1. Identity 2. Synthesis 3. Release 4. Receptors 5. Inactivation Inactivation mechanism enzymatic degradation reuptake
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Neurotransmitter Criteria 1. Identity 2. Synthesis 3. Release 4. Receptors 5. Inactivation 6. Pharmacology Same effect on ion channels; p.s.p.’s have same reversal potentials Same effect on membrane resistance and potential Applied substances must be effective in physiological concentrations Inhibition of degrading enzyme prolongs action of both
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Neurotransmitter Criteria 1. Identity 2. Synthesis 3. Release 4. Receptors 5. Inactivation 6. Pharmacology
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Receptor Subtypes Receptor Subtypes Neurotransmitters a b Drugs 1 2 3 4
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Acetylcholine Synthesis Choline + Acetyl CoA Acetylcholine + CoA Choline Acetyltransferase (ChAT) Degradation Acetylcholine Choline + Acetate Acetylcholine Esterase (AchE)
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Chemicals that Act on ACh Systems
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neuropharm - Neuropharmacology The Life of a Typical...

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