NTCRITER - c. mimicry of transmitter action by application...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Criteria for Identifying Neurotransmitters 1. Identity: Presence and storage in synaptic terminals. 2. Synthesis: Presence of precursors and enzymes necessary for synthesis. 3. Inactivation: Means of inactivating substance by enzymatic degradation or reuptake. 4. Release: Must be released from terminal; collect substance after nerve stimulation 5. Receptors: Post-synaptic target must have receptors for substance, as demonstrated by: a. cross desensitization between substance and endogenous neurotransmitter b. blockade of receptors by competitive antagonists of substance
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: c. mimicry of transmitter action by application of substance on target cell 6. Mimicry: Same physiological action of substance and endogenous neurotransmitter: a. open/close same ion channels in post-synaptic membrane b. post-synaptic potentials have same reversal potentials c. both induce same change in membrane resistance and potential d. inhibition of degrading enzymes prolongs action of both e. applied substances must be effective in physiological concentrations (10-8 to 10-5 molar)...
View Full Document

This note was uploaded on 12/01/2011 for the course PSB 6087 taught by Professor Stehouwer during the Fall '08 term at University of Florida.

Ask a homework question - tutors are online