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Unformatted text preview: Homework 1 (due 27 January 2005) Name _______________________________ STA 6178: Genetics Data Analysis Wu/Ma Problem 1 Allele frequencies Three alleles (denoted by A 1 , A 2 and A 3 ) were detected for the red cell acid phosphatase enzyme in a sample of 178 English people. All genotypes were distinguishable by electrophoresis and their frequencies in the sample were Genotype A 1 A 1 A 1 A 2 A 1 A 3 A 2 A 2 A 2 A 3 A 3 A 3 Frequency (%) 9.6 48.3 2.8 34.3 5.0 0.0 What are the gene frequencies in the sample? Data from Spencer et al. ( Nature 201 : 299-300, 1964). Problem 2 Hardy-Weinberg equilibrium As a candidate gene for human obesity, the 1-adrenergic receptor ( 1 AR) contains two common nonsynonymous polymorphism markers at codon 49 (Ser Gly) and codon 389 (Arg Gly). An ongoing project led by Dr. Julie Johnson at the University of Florida attempts to detect possible associations between these markers and obesity traits. To do so, however, we need to test if these associations between these markers and obesity traits....
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