Homework(1)a - Homework 1(due 27 January 2005 Name STA 6178 Genetics Data Analysis Wu/Ma Problem 1 Allele frequencies Three alleles(denoted by A1

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Homework 1 (due 27 January 2005) Name _______________________________ STA 6178: Genetics Data Analysis Wu/Ma Problem 1 – Allele frequencies Three alleles (denoted by A 1 , A 2 and A 3 ) were detected for the red cell acid phosphatase enzyme in a sample of 178 English people. All genotypes were distinguishable by electrophoresis and their frequencies in the sample were Genotype A 1 A 1 A 1 A 2 A 1 A 3 A 2 A 2 A 2 A 3 A 3 A 3 Frequency (%) 9.6 48.3 2.8 34.3 5.0 0.0 What are the gene frequencies in the sample? Data from Spencer et al. ( Nature 201 : 299-300, 1964). Answer: Frequency of A 1 = (9.6*2+48.3+2.8)/100*178 = 125 Frequency of A 2 = (48.3+2*34.4+5.0)/100*178 = 217 Frequency of A 3 = (2.8+5.0+0.0*2)/100*178 = 14 Rate of A 1 (%) = 125/(2*178) = 35 Rate of A 2 (%) = 217/(2*178) = 61 Rate of A 3 (%) = 14/(2*178) = 4 Problem 2 – Hardy-Weinberg equilibrium As a candidate gene for human obesity, the β 1 -adrenergic receptor ( β 1 AR) contains two common
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This note was uploaded on 12/01/2011 for the course STA 6178 taught by Professor Staff during the Fall '11 term at University of Florida.

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Homework(1)a - Homework 1(due 27 January 2005 Name STA 6178 Genetics Data Analysis Wu/Ma Problem 1 Allele frequencies Three alleles(denoted by A1

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