Exam 2 (2010)

Exam 2 (2010) - BIOL 3301 Midterm Exam #2 October 26, 2010...

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1 BIOL 3301 Midterm Exam #2 Morning blue October 26, 2010 There are a total of 9 pages in this exam. This exam consists of 34 questions worth a total of 100 points. All questions are multiple choice and there is one best answer for each question. Record your answers on the scantron sheet, and answer only once for each question or you will be automatically marked wrong. Use a #2 pencil. Name_________________________ ID#__________________________
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2 1. What general observation identifies two interacting genes? A. A mutation in either gene is lethal B. Mutations in only one of the genes produces an observable phenotype C. The combined effect of mutations in both genes is not the sum of their individual effects D. The combined effect of mutations in both genes is the sum of their individual effects E. Mutations in either gene produces a distinct phenotype 2. How can haploinsufficiency explain dominance of a null (loss of function) allele? A. A single functional copy of the gene produces sufficient gene product for normal biological function B. A single functional copy of the gene produces insufficient gene product for normal biological function C. The null allele produces a product that interferes with proper function of the normal allele D. The null allele produces a product that does not interfere with proper function of the normal allele E. The null allele rapidly mutates to reacquire normal functionality 3. A number of Neurospora mutants are obtained that require compound E for growth. Compounds A, B, C and D are known to be in the biosynthetic pathway leading to the production of E, but their order in the pathway is not known. Given the following growth requirements of three mutants, what is the most likely pathway order? (+ indicates growth when the tested compounds are present, ‐ indicates no growth when the tested compounds are present.) Compound tested: A B C D E Mutant: 1 + + 2 + + + 3 + + + + A. A‐>B‐>C‐>D‐>E B. B‐>A‐>C‐>D‐>E C. B‐>C‐>A‐>D‐>E D. E‐>D‐>A‐>C‐>B E. E‐>D‐>C‐>B‐>A
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3 4. What would you expect to happen during DNA replication in a cell lacking primase ( should say ligase )? A. DNA ahead of the replication fork would become increasingly tightly coiled. B. Okazaki fragments would not be joined. C. DNA polymerase I could not displace the RNA primer at the 5’ end of Okazaki fragments. D. Only lagging strand DNA synthesis would halt. E. All of the above. 5. What observations were crucial in allowing Watson and Crick to propose the double helix structure of DNA? A. Chargraff’s rule of the relative frequency of different nucleotides and Franklin’s X‐ray diffraction of the DNA molecule. B. Griffith’s observation of a transforming factor.
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Exam 2 (2010) - BIOL 3301 Midterm Exam #2 October 26, 2010...

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