Final (2009) - U niversity o f H ouston B CHS 3 304 A A...

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University of Houston BCHS 3304 A Briggs May8,zooqP'int.a-N;e- Adil r Aisho- Final Exam (B) Instructor Dr. Answer ALL questions. LAST, FIRST Multiple choice 2 pts each (100 pts total) - Choose the most correct answer and fill it in on the Scantron sheet. Please look at the last pages of the exam. There, you will find a table of half reactions, the gas constant, a Ramachandran diagram, and graph paper. Also circle your answer on the exam and show ALL work. That will help me reconcile your Scantron with your exam, if necessary. 1). The diagram represents a'osubstrate cycle" or "futile cycle" in glucose metabolism. Which of the following statements about the cycle is correct? a). Reactions I & II are catalyzed by the same enzyme and help establish an equilibrium between the two metabolites. b). Reaction II produces ATP by substrate-level phosphorylation. c). Reaction I is involved in the biosynthesis of glucose. @ Reaction I is catalyzedby an allosteric enzyme that is activated by fructose-2-6-bisphosphate. -6-P Fru-1,6-B e). Reaction II occurs under low-energy conditions when the cell needs ATP. -lf.2). Compute the AG' for a reaction with a IQo of 4.56 x l0-5. -F| q. -22.7 kJlmol n -bY 24,800kJ/mol AG = -RTlnK .rx_z+.goo kJ/mol _ ;.ce { @zi.i-utr^or (8.3t'fsxrs3)(rrre) (ln r+"rioxro-s) (e\ -24.8 kJ/mol .,-/ A6.= - p e. ,,oc @ T= O* g 2{,8 Q rE 35og 3). Mannose can be metabolized through the glycolysis pathway but it must first be converted into mannose-6-phosphate by hexokinase and then converted into fructose-6-phosphate, an intermediate in the glycolysis pathway, by ENZYME B. What is the identity of ENZYME-B? a). Pyruvate Kinase (6) Hexokinase c). Phosphofructokinase ,d). Phosphoglucose isomerase lA Pnorotromannose V 4). What form of this amino acid cannot exist in the pH range 7-14? H HrN-?-coo- lcHr)+ a). NH, H HrN-?-CoO- lcnz)a b). NH.+ n NH.+-g-6gqg fct')o NH^+ e). H NH,+-C-COO- -l (CH,)o t- c). LI u \t-^-^n^u ' '2'r Y vvvr ' (CH,)O @
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5). The ubiquitous chemistry of acetyl-CoA is centered on its high-energy a). phosphoester @ thio"tt"t tt phosphoanhydride d). phosphothioester e). ester 9Ho@ a). 2R,3R,4R .*tr 25,3R,4R 4f 2R,3S,4R G) 2R,3R,4S .*f,2S,3S,4R G s-+R s':r R Qn -+5 AR c lo -^ C\lotr i'o- \ 5 CilzOtl Qe's frl ** is the stereochemistry of each of the chiral centers in the following molecule (R or S)? onO oH@ t@ 3R, +S 7). What is the only compound that can phosphorylate the unphosphorylated catalytic histidine residue in phosp{oglycerate mutase (PGM)? ( a\ 2,3 -Bisphosphoglycerate Y;. Z-lhosphoglycerate c). 3-Phosphoglycerate d). 1,3-Bis-phosphoglycerate e). Phosphoenolpynrvate 8). The Bohr effect is related to the a). BPG ionization at 30 torr (the pO2 in veins). b). abilify of hemoglobin to bind oxygen in the presence of BPG. ,Q. ability of myoglobin to expel protons when binding oxygen. fu!) ability of hemoglobin to release protons when binding oxygen. e). ability of hemoglobin to bind four hemes. d 9). Which of the following enzymes from the citric acid cycle is inhibited by NADH? a). Aconitase fiJ. Citrate synthase v'. cl. Iumarase d). Succinate dehydrogenase e). Malate dehydrogenase bond.'
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10). Which of the following enzymes of the citric acid cycle is responsible for the production of the CO2? a). Succinyl-CoA synthetase
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This note was uploaded on 12/02/2011 for the course BCHS 3304 taught by Professor Johnson during the Spring '08 term at University of Houston.

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Final (2009) - U niversity o f H ouston B CHS 3 304 A A...

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