Ch06_GenePred_sim_selected

Ch06_GenePred_sim_selected - Gene Prediction:...

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Unformatted text preview: Gene Prediction: Similarity-Based Approaches (selected from Jones/Pevzner lecture notes) An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Using Known Genes to Predict New Genes Some genomes may be very well-studied, with many genes having been experimentally verified. Closely-related organisms may have similar genes Unknown genes in one species may be compared to genes in some closely-related species An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Similarity-Based Approach to Gene Prediction Genes in different organisms are similar The similarity-based approach uses known genes in one genome to predict (unknown) genes in another genome Problem: Given a known gene and an unannotated genome sequence, find a set of substrings of the genomic sequence whose concatenation best fits the gene An Introduction to Bioinformatics Algorithms www.bioalgorithms.info Comparing Genes in Two Genomes Small islands of similarity corresponding to similarities between exons An Introduction to Bioinformatics Algorithms...
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Ch06_GenePred_sim_selected - Gene Prediction:...

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