Biolog 13 - Chapter 13 DNA Structure and Function DNA as...

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Chapter 13: DNA Structure and Function I. DNA as genetic material A. Miescher discovered that DNA held the information about reproducing traits in offspring B. Griffith proposed that some unknown “principle” had transformed harmless R strain of Diplococcus to S strain in the mice experiment C. Oswald Avery, Maclyn McCarty, and Colin MacLeod announced that the transforming substance was DNA. Followed up on work done by Frederick Griffith in 1928 on the ability of one strain of bacteria which caused pneumonia in mice to transform a strain that could not cause pneumonia. D. In 1952, Alfred Hershey and Martha Chase showed that DNA was the genetic material of a bacteriophage. They used radioactive S to label the protein of the bacteriophage and allowed it to infect the host bacterium. After centrifugation, the radioactive protein was found in the supernatant. This showed that protein is not injected into host. Then, radioactive P was used to label the nucleic acid of the virus. After infection and centrifugation, the radiation was in the pellet with the bacterial cells. This showed that nucleic acid is injected into host bacterium during infection. E. In 1947, Erwin Chargaff had made a couple of observations regarding the composition of DNA. He noted that: 1. The DNA composition varies from species to species. 2.
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Biolog 13 - Chapter 13 DNA Structure and Function DNA as...

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