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Alzheimer's disease

Alzheimer's disease - Clinical Case Analysis#2 ALZHEIMERS...

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Clinical Case Analysis #2 ALZHEIMER’S DISEASE Alzheimer’s disease is a neurodegenerative condition that is due to the buildup of amyloid plaques. These plaques are known as deposits that grow extensively in neurons. The plaques result from a breaking away of fragments of a protein whose function is not completely known. The protein is a 770-residue transmembrane spanning protein that is known as A-beta precursor protein (beta-PP). After mutations occur in the enzyme that alters the structure of beta- PP (amyloid-beta-protein), fibrils start to form due to the fragments stacking. Even before amyloid deposits appear, neurons around the mutated proteins begin to die in result of its neurotoxic effect. Symptoms that result from Alzheimer’s disease are progressive loss of memory and cognitive function. These are thought to be due to the abundant fibers formed in the extracellular matrix. These fibers result in the degeneration of neurites surrounding them. The buildup occurs mainly in cholinergic neurons, which are neurons that release acetylcholine. These neurons are
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