Aerosol - AEROSOLS DEFINITION: An aerosol comprises of...

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AEROSOLS
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DEFINITION: ± An aerosol comprises of solid or liquid particles suspended in a gas ± GOALS : High efficiency of drug delivery Reproducible dosing Targeted delivery to site of action Ease of device operation Short duration of treatment Minimized risk to the patient and clinician Cost - effectiveness
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CLASSIFICATION OF AEROSOLS ± BLAND: include heated or cooled sterile water/ saline ² MEDICATED: bronchodilators, steroids, mucokinetic agents , ant allergic agents, local anesthesia, antimicrobials, surfactant, insulin , vosopressin
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AEROSOL PHYSICS ± The depth of aerosol delivery is a function of many variables-- ¾ -size and physical characteristics of the aerosol ¾ - amount of aerosol ¾ - anatomy and geometry of the airway ¾ - ventilatory pattern
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DEPOSITION OF AEROSOLS ± Deposited by 3 mechanisms: diffusion, inertial impaction and sedimentation Filtered by URT >100 u Mouth, nose & upper airway 5-100 u Bronchi & bronchioles 2-5 U Alveoli 0.5-2 U Stable (no deposition) <0.5 U SITE SIZE (MMAD)
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INDICATIONS OF AEROSALS ± DIAGNOSTIC : - Ventilation scans - Airway responsiveness & bronchodilator reversibility - Dosimetry ² THERAPEUTIC: - Treatment of airway and lung parenchymal diseases - Systemic diseases ( D.M , D.I )
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INHALED THERAPIES Bronchodilators, anti-inf. Asthma Vasodilators Pulm. HTN Bronchodilators, anti- inflammatories COPD exacerbation Antibiotics, surfactant Pneumonia / sepsis Surfactant, anti- inflammatories ARDS THERAPY DIAGNOSIS
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METHODS OF AEROSOL GENERATION ± NEBULIZERS: Pneumatic : - small volume, large volume small particle generator Ultrasonic ± METERED DOSE INHALERS:- (+ accessory device: spacer / chamber / spring loaded actuator) ± DRY POWDER INHALERS :– Rotahaler/ spinhaler/ turbohaler/ diskhaler
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NEBULIZERS ± Pneumatic/ Jet nebulizers :- work on Bernoulli’s principle ± Small volume nebulizer (SVN): Hand-hold nebulizers / ventilator circuits -gas flow rates : 6-8 l / m -optimal volume : 4-5ml -particle size : 1-5 u -10% of aerosol reaches its site of action -not ideal mode of aerosol delivery
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This note was uploaded on 12/03/2011 for the course MEDICINE 350 taught by Professor Dr.aslam during the Winter '07 term at Medical College.

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Aerosol - AEROSOLS DEFINITION: An aerosol comprises of...

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