IPF Mx - IPF IPFmanagement,recent...

Info iconThis preview shows pages 1–8. Sign up to view the full content.

View Full Document Right Arrow Icon
F management recent IPF management, recent advances and future directions Dr. Sunil Sharma Senior Resident Department of Pulmonary Medicine
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
troduction Introduction Idiopathic Pulmonary Fibrosis (IPF) is the most common form of interstitial lung diseases of unknown origin. It is associated with an extremely poor rognosis for survival in most patients prognosis for survival in most patients. Life expectancy after diagnosis varies, but is on average less than 5 years.
Background image of page 2
troduction Introduction The mainstay of therapy has been the use of rticosteroids with or without immunosuppressive corticosteroids with or without immunosuppressive drugs. hest 123 (3): 759 61 (2002). Chest 123 (3): 759 761 (2002). erapies with anti flammatory drugs are Therapies with anti inflammatory drugs are associated with toxicity and do not provide objective benefit
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ANTI INFLAMMATORY AGENTS nti flammatory therapies continue to be used despite there being little Anti inflammatory therapies continue to be used despite there being little evidence of inflammation in the pathogenesis of IPF Although corticosteroid with or without immunosuppressive drugs were the mainstay of therapy for IPF for decades, their efficacy is unproven and xicities are substantial toxicities are substantial . Am. J. Respir. Crit. Care Med. 171 (9): 939 940 (2005). Ann. Intern. Med.134:136 151 (2001). In a majority of cases of IPF, corticosteroid therapy is only partially effective, and most patients deteriorate despite therapy.
Background image of page 4
There is no controlled trial using corticosteroids alone for the treatment of F IPF Cochrane Database Syst. Rev. 3:CD002880 (2003). ny conclusive evidence supporting the use of corticosteroid therapy for Any conclusive evidence supporting the use of corticosteroid therapy for the treatment of IPF is lacking Eur Respir. J.626:693 702 (2005) . Given the poor prognosis of the disease and the lack of readily available alternatives and efficacious treatment, a therapeutic trial with anti inflammatory medications is still justified Thorax 54:S1 S30 (1999). F respond better to therapy if they exhibit more inflammation and less IPF respond better to therapy if they exhibit more inflammation and less fibrosis
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
ANTI FIBROTIC AND ANTI CYTOKINE AGENTS Trend toward using anti fibrotic treatment, based on the concept that the disease is a fibrotic process with lack of significant inflammation a lack of significant inflammation Anti fibrotic drugs that interfere with or modulate further progression of lung fibrosis may have potential to improve respiratory function Mayo Clin. Proc. 72(2):285 287 (1997)
Background image of page 6
ANTI FIBROTIC AND ANTI CYTOKINE AGENTS Anti cytokine therapeutic strategies are directed at abrogating the activities of the targeted cytokines that have diverse regulatory activities in several processes that comprise fibrosis.
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Image of page 8
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 12/03/2011 for the course MEDICINE 350 taught by Professor Dr.aslam during the Winter '07 term at Medical College.

Page1 / 67

IPF Mx - IPF IPFmanagement,recent...

This preview shows document pages 1 - 8. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online