Aging preg excercise web

Aging preg excercise web - LUNG: Effects of Aging, LUNG:...

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LUNG: Effects of Aging, LUNG: Effects of Aging, AS Paul AS Paul DM Seminar DM Seminar 13 Jan 06 13 Jan 06
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Effects of Age Effects of Age Life expectancy is increasing US 47yrs(1900) to 71yrs (2001) India 63.7 yrs Decreased reserve Management and outcome of LRTI,HF
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Structural Changes Structural Changes DECREASE IN: Chest wall compliance Static elastic recoil of lung Strength of resp muscles
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Chest Wall Chest Wall Upper thorax/Rib cage Calcification Osteoporosis (wedge/crush # 34% 75-79) Kyphosis (25% severe 43% moderate 23% N) Lower thorax/Diaphragm abdo compartment
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Resp Resp muscle function muscle function Rib cage shape Decreased compliance Increased FRC (elastic recoil decreased) Flatter diaphragm(AP, Kyphosis) MIP, MEP decrease Increase in energy expenditure 20% (60y vs 20y)
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Muscle strength Muscle strength Under nourishment (Diaphragm mass) Skeletal muscle strength (handgrip,sarcopenia,number,NM jn,muscle proteins, mito. Oxidative capacity) CHF, Parkinson’s,CVA,Myaesthenia
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Pollution?? Normal aging vs env exposure (tob/part) Animal models eg SAM Alveolar duct size No cellular infiltrate Lung wt:body wt constant Loss of recoil Compare to emphysema
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PFT PFT Quality Mood Fatigue Co-operation Cognitive impairment(dementia 22% at 80) Alternative methods
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Lung Volumes Lung Volumes Loss of recoil: – Increase in RV (50% 20-70 yrs) – Decreased VC (75% of best value) – TLC remains constant Closing volume increases – Decrease in PaO2 – Increase in alv art difference
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Spirometry Spirometry
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This note was uploaded on 12/03/2011 for the course MEDICINE 350 taught by Professor Dr.aslam during the Winter '07 term at Medical College.

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Aging preg excercise web - LUNG: Effects of Aging, LUNG:...

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