dlco - DM Seminar 23.01.04 Diffusion Capacity Puneet...

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DM Seminar 23.01.04 Diffusion Capacity Puneet Malhotra Dept. of Pulmonary Medicine, PGIMER Physiology of diffusion Terminology Measurement of diffusion capacity Importance in respiratory diseases
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Physiology Primary function of lung: gas exchange Simple passive diffusion Fick’s law of diffusion
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Pathway for diffusion
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Terminology North America: “Diffusing capacity” Europe: “Transfer factor” Gas exchange involves more than just diffusion It is also a submaximal index & not a capacity
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Why is CO preferred? not normally present in alveoli/blood transfer is diffusion limited rather than perfusion limited Avidly binds to Hb CO diffusion is less affected by other factors
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Measurement of diffusing capacity Methods Single breath-holding method Single expiration method Rebreathing method Steady state method Riley-Lilienthal method Technique patient conditions inspiratory maneuver breath-hold expiratory maneuver
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Single breath vs. Steady state Easy for the lab Well standardized Less affected by nonuniformity of
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This note was uploaded on 12/03/2011 for the course MEDICINE 350 taught by Professor Dr.aslam during the Winter '07 term at Medical College.

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dlco - DM Seminar 23.01.04 Diffusion Capacity Puneet...

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