Malignant Mesothelioma

Malignant Mesothelioma - Malignant Mesothelioma Recent...

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1 Malignant Mesothelioma Recent Advances Dr AS Paul 04 Aug 06 DM Seminar Malignant mesothelioma ± A tumour of serosal surfaces ± Pleura, peritoneum ± Increasing incidence worldwide ± Association with asbestos exposure ± Compensation costs over 40 yrs ± $200 billion US ± $80 billion Europe
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2 India ± 100 000 tonnes used annually ± 1/5 th mined in India. ± AP,Rajasthan, Bihar ± 9 th largest producer ± 6 th largest user ± 13 large scale/ 673 small scale industries ± 6000 workers in direct contact Advances ± Diagnosis ± Management ± Reviews ± Advances in Malignant mesothelioma ² N Engl J Med 2005:353:1591-603 ± Malignant mesothelioma ² Lancet 2005; 366;397-408
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3 Clinical Features ± Pleura ± 80% male ± Effusion ± Chest wall pain ± Wt loss and fatigue ± Peritoneum ± Ascites ± Abdominal pain ± Bowel obstruction ± Extensive at presentation (closed cavity) ± Local invasion ² LN enlargement ² SVCO ² Cardiac tamponade ² SCextensions ² Cord compression ± Miliary spread
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4 Signs ± Effusion/ascites ± Clubbing<1% ± Fixed chest wall ± SC masses (tracks,surg sites) ± Cancer syndrome ± Wt loss,cachexia ± Fever, night sweats ± Fatigue, ESR, anaemia ± IL-6
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5 Causes ± Asbestos ± Amphiboles: long thin fibres/blue asbestos ± Chrysotile:feathery/white asbestos ± Parietal surface ± Repeated trauma,inflammation,repair Simian virus 40 ± Potent oncogene ± SV 40 DNA (bone/ lung tumours) ± Role unproven ± Sabin polio vaccine ± Radiation ± Zeolite (Erionite) Turkey
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This note was uploaded on 12/03/2011 for the course MEDICINE 350 taught by Professor Dr.aslam during the Winter '07 term at Medical College.

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Malignant Mesothelioma - Malignant Mesothelioma Recent...

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