ventilation - Physiology of ventilation& work of...

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Unformatted text preview: Physiology of ventilation & work of breathing Puneet Malhotra Dept. of Pulmonary Med, PGIMER 20.03.04 Goals of respiration 1.Ventilation 2.Diffusion of O 2 & CO 2 3.Transport of O 2 & CO 2 4.Regulation of respiration Ventilation • Movement of air in & out of lungs the airways respiratory muscles dead space ventilation • Measurement of ventilation • The work of breathing • Importance in the ICU Movement of air in & out of lungs The airways Anatomic dead space Respiratory Muscles quadriplegics COPD Inspiration Expiration The diaphragm Hoover’s sign Effect of posture on respiratory muscles Upright: FRC Supine: FRC Lateral: The pressures • Pressure differences > airflow • P pl precede P alv • P alv and air flow in phase • At points of no flow P alv = 0 Dead space ventilation • 3 types • Anatomic dead space 1ml/lb ideal body wt., 150 ml/500ml VT VT- anat dead space/VT ratio e.g.150/500=30%, 150/300=50% can gas exchange occur if pt. is ventilated with VT< anat dead space? VA = f x [V T - V D ] Yes: high freq ventilation • Alveolar dead space...
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ventilation - Physiology of ventilation& work of...

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