430 neurogenesis final

430 neurogenesis final - Pregnancy-Stimulated Neurogenesis...

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Pregnancy-Stimulated Neurogenesis in the Adult Female Forebrain Mediated by Prolactin Me Tetsuro Shingo, Christopher Gregg, Emeka Enwere, Hirokazu Fujikawa, Rozina Hassam, Colleen Geary, James C. Cross, Samuel Weiss (2003) Anna B., Tiffany S., & Michelle W.
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Seminar Outline Introduction Neurogenesis Discovery and comparative studies Pregnancy hormones Methods and Results Strength and Limitations Progress in Neurobiology Prolactin role in neurogenesis Induction of neurogenesis Future Directions and Research
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Neurogenesis Neurogenesis is a process by which neurons are generated. Neurons are created in predominantly two areas of the brain. Subventricular zone (SVZ) new cells migrate to the olfactory bulb via the rostal migratory stream Subgranular zone (SGZ) part of the dentate gyrus of hippocampus
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Neural stem cells (NSCs) Self-renewing, multipotent cell Can differentiate into three main lineage cell types of the nervous system Neurons Astrocytes Oligodendrocytes http://www.rienstraclinic.com/newsletter/2007/images/2007J an_2neurogenesis.jpg
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Pathway of neurogenesis in the SVZ Purple: A cells (neuroblast) Green: B cells (astrocytic features, divides slowly, ensheath migrating type A c Red: C cells (derived from type B cells, rapidly dividing, gives rise to type A ce Type B Type C  Type A www.crulrg.ulaval.ca/. ../Saghatelyan_Fig1.jpg
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Pathway of neurogenesis in the SVZ Proliferating cells (precursor cells) Differentiation into an immature neurons Neuroblasts (Neuronally committed) Migration of cells to olfactory bulb Within few days-grow and mature into fully functional neuron Granule and periglomerular neurons
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What affects neurogenesis? Corticosterone (stress) and antidepressants were found to affect cell proliferation in hippocampus Scheffler et al. (2005) study shows that: 1) corticosterone decreases cell proliferation in SVZ 2) antidepressant promotes SVZ cell proliferation Aging decreases cell proliferation
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“no new neuron” dogma
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Neurogenesis found in adult mammals Weiss and Reynolds (1992) Isolated NSCs from SVZ of mouse brains Alvarez-Buylla and Lois (1994) Showed NSCs form neurons that travel to OB (brain area that receive sensory info from nose) Gage et al. (1996) Found new neurons in hippocampus (memory) of adult mice and humans
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What do these new neurons do? 1. Song Production -Nottebohm et al. (2000) New neurons migrated to HVC for replacement Loss of neurons in HVC=song degraded Suggested neurogenesis vital in song production 2. Odor Recognition- Lledo et al. (2000) New neurons join granule cells, which are activated by neurons that respond to odors Inhibit neighbouring cells=lateral inhibition Sharpen neural activity evoked by an odor http://people.eku.edu/ritchisong/RITCHISO/songbraincircuits
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Pregnancy is an adaptive state Pregnancy involves physiological changes in all major body systems.
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This note was uploaded on 12/06/2011 for the course BIOL 430 taught by Professor Dr.ianchin-sang during the Winter '10 term at Queens University.

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430 neurogenesis final - Pregnancy-Stimulated Neurogenesis...

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