BIOL 430 2010 lecture 4 handout

BIOL 430 2010 lecture 4 handout - Lecture 4 Model...

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Lecture 4 odel Vertebrates: Frog Chick Mouse and Fish Model Vertebrates: Frog, Chick, Mouse and Fish (See Wolpert et al. Chapter 3 pp. 89-108) Intro/ review of Molecular Techniques used in Developmental Biology January 19 th , 2010 BIOL 430 2010 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Is DNA the “blueprint” of life? - plications of sequencing the entire human genome Implications of sequencing the entire human genome created more questions than answers -The genes encoded on the DNA represent a “parts list” not a blueprint which implies details in construct and the sequence itself does not give construction plans. 747 jumbo jet analogy - Model organisms and the conservation of genetic and molecular mechanisms—all living things share gg common genes. VW beetle vs. jet analogy
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Model organisms in developmental biology lthough people are mostly interested in human Although people are mostly interested in human development (for egocentric reasons), many aspects of development are conserved in distantly related pecies species. • The major model organisms used to study the principles of development are. .. – nematode ( Caenorhabditis elegans ) – fruit fly ( Drosophila melanogaster ) ea urchins ( trongylocentrotus purpuratus sea urchins ( Strongylocentrotus purpuratus ) – South African claw-toed FROG ( Xenopus laevis ) – chick (Gallus gallus) – mouse (Mus musculus) – Zebrafish ( Danio rerio) lime mold ( ictyostelium discoideum – slime mold ( Dictyostelium discoideum ) – plant ( Arabidopsis thaliana )
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Figure 1.1 from: lfonso Martinez Alfonso Martinez Arias and Alison Stewart Molecular Principles of Development xford University BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Oo d U e s t y Press 2002
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Model organisms in development A few have been studied extensively; each has advantages and disadvantages. Xenopus laevis (frog): development is independent but poor genetics. Large embryos, transplantation experiments. Chick: available, surgical manipulation and in vitro culture but poor genetics. Mus musculus (Mouse): warm blooded, ood genetics but development is good genetics but development is in utero. Sequenced genome ~2,500Mb ~30,000 predicted genes) BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) ( 30,000 predicted genes)
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Drosophila (fruit fly): great genetics, rapid evelopment (Nobel Prize to Lewis development (Nobel Prize to Lewis, Nusslein-Volhard & Wiechaus 1995). equenced genome ~160 Mb ( 3 767 Sequenced genome ~160 Mb (13,767 genes)- textbook wrong says 20,000 (p.18) C. elegans (nematode): has less than 1000 ells and is transparent Fast life cycle cells and is transparent. Fast life cycle. Cell lineage, great genetics (3 Nobel rizes: Brenner Sulston ovitz 002 Fire Prizes: Brenner, Sulston, Hovitz 2002, Fire and Mello 2006, and Marty Chalfie et al.
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This note was uploaded on 12/06/2011 for the course BIOL 430 taught by Professor Dr.ianchin-sang during the Winter '10 term at Queens University.

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BIOL 430 2010 lecture 4 handout - Lecture 4 Model...

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