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BIOL 430 2010 lecture 4 handout

BIOL 430 2010 lecture 4 handout - Lecture 4 Model...

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Lecture 4 Model Vertebrates: Frog Chick Mouse and Fish Model Vertebrates: Frog, Chick, Mouse and Fish (See Wolpert et al. Chapter 3 pp. 89-108) Intro/ review of Molecular Techniques used in Developmental Biology January 19 th , 2010 BIOL 430 2010 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Is DNA the “blueprint” of life? -Implications of sequencing the entire human genome Implications of sequencing the entire human genome created more questions than answers -The genes encoded on the DNA represent a “parts list” not a blueprint which implies details in construct and the it lf d t i t ti l sequence itself does not give construction plans. 747 jumbo jet analogy - Model organisms and the conservation of genetic and molecular mechanisms—all living things share common genes. VW beetle vs. jet analogy
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Model organisms in developmental biology Although people are mostly interested in human Although people are mostly interested in human development (for egocentric reasons), many aspects of development are conserved in distantly related species species. The major model organisms used to study the principles of development are... – nematode ( Caenorhabditis elegans ) – fruit fly ( Drosophila melanogaster ) – sea urchins ( Strongylocentrotus purpuratus ) sea urchins ( – South African claw-toed FROG ( Xenopus laevis ) – chick (Gallus gallus) – mouse (Mus musculus) – Zebrafish ( Danio rerio) slime mold ( Dictyostelium discoideum ) – slime mold ( – plant ( Arabidopsis thaliana )
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