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Unformatted text preview: 1 BIOL 430 Lecture 5: January 20 th 2010 Techniques contd Model Systems: Fly, Worm, See Wolpert Chapter 2 pp. 31-38 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Chapter 5 pp.185-191 Seminar Presentations: Your article will stay the same even if your partner drops the course. If your partner drops: 1. I will assign a new partner from the waiting list or Notes and Announcements BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) 2. You will present by yourself (or just two people will present) Please note: You should read the Entire paper(s) Even if you plan to present half the paper it is necessary to understand the whole article. Definition of a gene: WordNet: a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity. Wikipedia: A gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain an organism's cells and pass genetic traits to offspring. Answers.com: A hereditary unit consisting of a sequence of DNA that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their DNA sequence changes Websters : a specific sequence of nucleotides in DNA or RNA that is located usually on a chromosome and that is the functional unit of inheritance controlling the transmission and expression of one or more traits by specifying the structure of a particular polypeptide and especially a protein or controlling the function of other genetic material. Oxford: a distinct sequence of DNA forming part of a chromosome, by which offspring inherit characteristics from a parent. Genes IX: is the segment of DNA involved in producing a polypeptide chain ; it includes regions preceding and following the coding region as well as intervening sequences between individual coding segments BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Definition of a GENE has evolved with time: Definition 1860s1900s: Gene as a discrete unit of heredity Definition 1910s: Gene as a distinct locus Definition 1940s: Gene as a blueprint for a protein Definition 1950s: Gene as a physical molecule Definition 1960s: Gene as transcribed code Definition 1970s1980s: Gene as open reading frame (ORF) Definition 1990s2000s: Annotated genomic entity, enumerated in the databanks (current view) Human Genome Nomenclature Organization : a DNA segment that contributes to phenotype/function. In the absence of demonstrated function a gene may be characterized by sequence, transcription or homology A gene is a union of genomic sequences encoding a coherent set of potentially overlapping functional products....
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