BIOL 430 2010 Lecture 5 handout

BIOL 430 2010 Lecture 5 handout - BIOL 430 Lecture 5...

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BIOL 430 Lecture 5: January 20 th 2010 Techniques cont’d Model Systems: Fly, Worm, See Wolpert Chapter 2 pp. 31-38 hapter 5 pp.185- 91 Chapter 5 pp.185 191 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Seminar Presentations: Notes and Announcements Your article will stay the same even if your partner drops the course. If your partner drops: 1. I will assign a new partner from the waiting list or 2. You will present by yourself (or just two people will resent) present) Please note: You should read the Entire paper(s) Even if you plan to present half the paper it is necessary to understand the whole article. BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Definition of a gene: WordNet: a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity. Wikipedia: A gene is the basic unit of heredity in a living organism. All living things depend on genes. Genes hold the information to build and maintain an organism's cells and pass genetic traits to offspring. Answers.com: A hereditary unit consisting of a sequence of DNA that occupies a specific location on a chromosome and determines a particular characteristic in an organism. Genes undergo mutation when their NA h DNA sequence changes Websters : a specific sequence of nucleotides in DNA or RNA that is located usually on a chromosome and that is the functional unit of inheritance controlling the transmission and expression of one or more traits by if i th t t f ti l l tid d i ll t i t lli th f ti f specifying the structure of a particular polypeptide and especially a protein or controlling the function of other genetic material. Oxford: a distinct sequence of DNA forming part of a chromosome, by which offspring inherit t i t i f t characteristics from a parent. Genes IX: is the segment of DNA involved in producing a polypeptide chain ; it includes regions preceding and following the coding region as well as intervening sequences between individual coding segments BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Definition of a GENE has evolved with time: Definition 1860s–1900s: Gene as a discrete unit of heredity Definition 1910s: Gene as a distinct locus Definition 1940s: Gene as a blueprint for a protein Definition 1950s: Gene as a physical molecule Definition 1960s: Gene as transcribed code Definition 1970s–1980s: Gene as open reading frame (ORF) efinition 1990s 000s: Annotated genomic entity enumerated in Definition 1990s–2000s: Annotated genomic entity, enumerated in the databanks (current view) Human Genome Nomenclature Organization : “a DNA segment that contributes to phenotype/function. In the absence of demonstrated function a gene may be characterized by sequence, transcription or homology” “A gene is a union of genomic sequences encoding a coherent set of
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BIOL 430 2010 Lecture 5 handout - BIOL 430 Lecture 5...

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