BIOL 430 2010 lecture 9 handout

BIOL 430 2010 lecture 9 handout - BIOL 430 Lecture 9...

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BIOL 430 Lecture 9 January 29 th 2010 Handedness Origin and specification of the germ yers layers Mesoderm Induction BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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Signal Transduction in Development 1. Ligand (extracellular) 2. Receptor (on membrane) 3. Effectors (A,B, C i.e. adaptors, kinases, phosphatases ) 4. Regulation of of transcription 1. 5. Changes in actin/cytoskeleton 2. A B 5. C 3. Off On On Transcription BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) 4. nucleus
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997 June 2004 1997 wild type gdf-8 knock out (myostatin) BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) myostatin mice [PDF]
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Organ Handedness is under genetic control shh : secreted molecule, ectopic expression can lead to ft/right heart randomization Fig. 3.41 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) left/right heart randomization activin, lefty, nodal : all TGF- β like molecules pitx2 : transcription factor—key player in “leftness”
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Can the beating of cilia set up left-right asymmetries? t heart looping (left) eart looping (right) wt heart looping (left) iv heart looping (right) 50% ig 3 40 iv encodes left/right dynein motor protein artagener’s syndrome: 50% show itus inversus nd respiratory Fig. 3.40 Kartagener s syndrome: 50% show situs inversus and respiratory problems cilia fail to beat in respiratory lining (lacks dynein) Cells on node have cilia that beat in one direction— BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) early asymmetry?
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ig 3 42 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca) Fig 3.42
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Fate Map Specification map ig 3 54 No neural tissues develops from explants of cells from the animal half and muscle develops only from Fig. 3.54 Fig. 3.44 the most dorsal mesoderm. Therefore these tissues have not been specified.
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Fig. 3.50 BIOL 430 Molecular Genetics of Development 2010 Dr. Ian Chin-Sang (www.chin-sang.ca)
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When cultured separately animal cap cells or egetal cells do not differentiate mesoderm Only Fig. 3.50 vegetal cells do not differentiate mesoderm. Only when cultured together mesoderm is formed uscle and notochord).
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This note was uploaded on 12/06/2011 for the course BIOL 430 taught by Professor Dr.ianchin-sang during the Winter '10 term at Queens University.

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BIOL 430 2010 lecture 9 handout - BIOL 430 Lecture 9...

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